Table 1

Genes previously reported to be regulated by transforming growth factor beta (TGF-β)

Response

Response



Gene

1 hour

6 hours

24 hours

Gene

1 hour

6 hours

24 hours


Cellular communication

Cell cycle regulator

Platelet-derived growth factor

No

Up**

Up***

CDK2 interacting protein (CINP)

Down*

No

Down*

Fibroblast growth factor regulated

Up**

Up***

Up***

Cyclin D2

No

Down*

Down*

Cadherin 1 (Cdh1)

No

Down*

No

Cyclin D3

Up*

No

No

Signal transduction

CDK9

Up*

Up**

Up*

Nfkb inducing kinase

Up**

No

No

Cdk4

Down*

No

No

RhoB

Up***

Up***

Up**

Cyclin A2

Down*

No

Down*

Serine/threonine kinase 25

No

Up*

No

Cyclin B1

No

No

Down**

Integrin β4

No

Up**

No

Cyclin B2

Down*

No

Down*

Bmp-1

No

Up*

Up*

Cdc25a

No

Up*

No

Janus kinase 2 (Jak2)

No

No

Up*

Cyclin H

No

No

Down*

Integrin α3A

No

No

Up*

Cancer

Integrin β1

No

Up*

Up**

c-myc

Down**

Down*

No

Integrin-linked kinase (Ilk)

No

Up*

Up*

Akt

Up**

No

No

Integrin β5

Up*

Up**

Up***

GRO1 oncogene

Down**

Down**

Down**

Tyrosine phosphatase PTPT9

No

Up*

Up*

Jun oncogene

Up**

No

Up*

Ephrin-A1 (EFNA1)

Up*

No

No

E2 oncogene (Ets1)

Up**

Up**

Up*

BMP-6

No

Up*

Up**

Transport

TGF-β1-induced transcript

Up*

Up**

Up***

Glucose transport protein

Up*

No

No

Colony stimulating factor 1

Up**

Up**

Up***

Ubiquitins and elongation factors

Intracellular components

Elongation factor 2 (ef-2)

No

Up**

Up**

TG interacting factor (Tgif)

Up*

Up**

Up**

Ubiquitin conjugating enzyme

Up*

Up*

Up*

α-actinin

No

Up**

Up**

Enzyme

β-tropomyosin 2

No

Up*

Up***

Glutathione S-transferase

Down*

Down*

Down*

Catenin src (Catns)

No

Up*

Up*

Protein tyrosine phosphatase

Up*

No

No

Extracellular components

Protease serine 15 (PRSS15)

Up*

Up*

No

α1 type IV collagen

No

No

Up*

Aldose reductase

No

Up**

Up**

Fibronectin

No

Up*

Up***

Disulfide isomerase (ERp59)

No

Up*

No

Nucleic acid binding

Casein kinase II (Csnk2a2)

No

Up*

No

Helix-loop-helix DNA binding (Id)

Up***

Down***

Down***

Ornithine decarboxylase

No

Up**

Up**

Inhibitor of DNA binding (Idb3)

No

Down*

Down*

RNA polymerase II

No

No

Up*

Translation initiation factor 2

No

No

Up*

Bruton's tyrosine kinase (Btk)

No

Up*

Up*

Id2

No

Down*

Down*

Cytochrome b-5 reductase (DIA1)

No

No

Up*


The genes presented were upregulated (up) or downregulated (down) at least 2.5-fold (* 2.5-fold to fourfold, ** fourfold to sixfold, *** above sixfold) and were found in a Medline search in which the gene name and TGF-β1 were used as keywords. The genes are grouped according to their involvement in specific cellular functions.

Xie et al. Breast Cancer Res 2003 5:R187-R198   doi:10.1186/bcr640

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