Table 1

Genes previously reported to be regulated by transforming growth factor beta (TGF-β)

Response
Response


Gene
 1 hour
 6 hours
 24 hours
 Gene
 1 hour
 6 hours
 24 hours
Cellular communication


Cell cycle regulator


     Platelet-derived growth factor
 No
 Up**
 Up***
      CDK2 interacting protein (CINP)
 Down*
 No
 Down*
     Fibroblast growth factor regulated
 Up**
 Up***
 Up***
      Cyclin D2
 No
 Down*
 Down*
     Cadherin 1 (Cdh1)
 No
 Down*
 No
      Cyclin D3
 Up*
 No
 No
Signal transduction


     CDK9
 Up*
 Up**
 Up*
     Nfkb inducing kinase
 Up**
 No
 No
      Cdk4
 Down*
 No
 No
     RhoB
 Up***
 Up***
 Up**
      Cyclin A2
 Down*
 No
 Down*
     Serine/threonine kinase 25
 No
 Up*
 No
      Cyclin B1
 No
 No
 Down**
     Integrin β4
 No
 Up**
 No
      Cyclin B2
 Down*
 No
 Down*
     Bmp-1
 No
 Up*
 Up*
      Cdc25a
 No
 Up*
 No
     Janus kinase 2 (Jak2)
 No
 No
 Up*
      Cyclin H
 No
 No
 Down*
     Integrin α3A
 No
 No
 Up*
 Cancer


     Integrin β1
 No
 Up*
 Up**
      c-myc
 Down**
 Down*
 No
     Integrin-linked kinase (Ilk)
 No
 Up*
 Up*
      Akt
 Up**
 No
 No
     Integrin β5
 Up*
 Up**
 Up***
      GRO1 oncogene
 Down**
 Down**
 Down**
     Tyrosine phosphatase PTPT9
 No
 Up*
 Up*
      Jun oncogene
 Up**
 No
 Up*
     Ephrin-A1 (EFNA1)
 Up*
 No
 No
      E2 oncogene (Ets1)
 Up**
 Up**
 Up*
     BMP-6
 No
 Up*
 Up**
 Transport


     TGF-β1-induced transcript
 Up*
 Up**
 Up***
      Glucose transport protein
 Up*
 No
 No
     Colony stimulating factor 1
 Up**
 Up**
 Up***
 Ubiquitins and elongation factors


Intracellular components


     Elongation factor 2 (ef-2)
 No
 Up**
 Up**
     TG interacting factor (Tgif)
 Up*
 Up**
 Up**
      Ubiquitin conjugating enzyme
 Up*
 Up*
 Up*
     α-actinin
 No
 Up**
 Up**
 Enzyme


     β-tropomyosin 2
 No
 Up*
 Up***
      Glutathione S-transferase
 Down*
 Down*
 Down*
     Catenin src (Catns)
 No
 Up*
 Up*
      Protein tyrosine phosphatase
 Up*
 No
 No
Extracellular components


     Protease serine 15 (PRSS15)
 Up*
 Up*
 No
     α1 type IV collagen
 No
 No
 Up*
      Aldose reductase
 No
 Up**
 Up**
     Fibronectin
 No
 Up*
 Up***
      Disulfide isomerase (ERp59)
 No
 Up*
 No
Nucleic acid binding


     Casein kinase II (Csnk2a2)
 No
 Up*
 No
     Helix-loop-helix DNA binding (Id)
 Up***
 Down***
 Down***
      Ornithine decarboxylase
 No
 Up**
 Up**
     Inhibitor of DNA binding (Idb3)
 No
 Down*
 Down*
      RNA polymerase II
 No
 No
 Up*
     Translation initiation factor 2
 No
 No
 Up*
      Bruton's tyrosine kinase (Btk)
 No
 Up*
 Up*
     Id2
 No
 Down*
 Down*
      Cytochrome b-5 reductase (DIA1)
 No
 No
 Up*

The genes presented were upregulated (up) or downregulated (down) at least 2.5-fold (* 2.5-fold to fourfold, ** fourfold to sixfold, *** above sixfold) and were found in a Medline search in which the gene name and TGF-β1 were used as keywords. The genes are grouped according to their involvement in specific cellular functions.

Xie et al. Breast Cancer Res 2003 5:R187   doi:10.1186/bcr640

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