Table 2

Genes not previously reported to be regulated by transforming growth factor beta (TGF-β)

Response

Response



Gene

1 hour

6 hours

24 hours

Gene

1 hour

6 hours

24 hours


Cellular communication

Cell cycle regulator

Gadd45g

Up***

Up*

Up*

Calcyclin binding protein (CACYBP)

Up*

No

Up*

cdc2

No

Up*

Up*

E2F transcription factor 5 (E2f5)

Down*

Down*

Down*

Hsp84-1

No

Up*

Up*

Cancer

Junctional adhesion molecule (Jam)

No

Up*

Up*

Suppression of tumorigenicity 13

No

Up*

Up*

Catenin α1 (Catna1)

No

Up*

Up*

Candidate tumor suppressor p33 ING1

No

Up*

Up*

Signal transduction

Transport

NFKBIL2 gene for IκBR

No

Down***

Down**

Solute carrier family 4

Up**

Up**

Up*

GTPase-activating protein GIT1

Up*

Up*

No

ATPase, H+ transporting (ATP6J)

No

Up*

Up*

Ras-GTPase-activating SH3 binding

Up**

No

Up*

Ca2+/calmodulin-dependent kinase I

Up*

Up***

Up**

Ikki

Down*

Down*

Down*

Microtubular dynamics

Iqgap1

Up*

Up**

Up**

Kinesin light chain 1 (Klc1)

Up*

No

Up*

Milk fat globule-EGF factor 8 protein

No

Up*

Up**

Microtubule-associated protein 4

Up**

Up**

Up**

Tnfrh1 gene

Up*

No

Up*

Ubiquitin and elongation factors

Intracellular components

Ubiquitin-specific protease 5 (Usp5)

Up**

Up*

Up*

Actinin α3 (Actn3)

Up*

Up**

Up*

Elongation factor 1-alpha (EF 1-α)

No

Up**

Up***

Actin-related protein 2/3 complex

Up*

Up*

Up*

Chaperone

Unconventional myosin-15 gene

Up*

No

Up**

Ccth gene for chaperonin

Up*

Up*

Up**

Nonmuscle tropomyosin 5

No

Up*

Up*

Chaperonin subunit 7 (Cct7)

Up*

Up*

Up**

Melanoma X-actin (Actx)

No

Up*

Up**

Enzyme

Tropomyosin isoform 2

No

Up*

Up**

Phosphoserine aminotransferase

No

Down**

Down**

Actin-related protein 1

No

Up*

Up**

α-methylacyl coenzyme (Macr1)

No

Down**

Down**

Karyopherin β3 (KPNB3)

No

No

Up*

PLC-L2 for phospholipase C-L2

No

Down**

Down**

β-tropomyosin 2

No

Up*

Up***

Fatty acid coenzyme A ligase (FACL4)

No

Down**

Down**

TM-4 gene for fibroblast tropomyosin 4

No

Up**

Up**

Phospholipase A2, group 4 (Pla2g4)

No

No

Up*

Calpain

No

Up**

Up**

Serine/threonine kinase (Unc51.1)

No

Up*

Up**

Myosin light chain 2 (Mlc2)

No

Up*

No

Proteasome (Psmd13)

Up**

Up*

Up*

Extracellular components

Na, K-ATPase α-1

No

Up**

Up*

Cis-Golgi matrix protein GM130

Up**

No

Up*

Aldehyde dehydrogenase 5 (ALDH5)

Up*

Up*

No

α-1(XVIII) collagen (COL18A1)

No

Up*

Up**

Protein phosphatase 2A (PR 53)

Up*

No

Up*

Smarce1

No

Up*

Up*

Casein kinase 1 (Csnk1e)

Up*

Up*

Up***

Nucleic acid binding

Serine/threonine phosphatase-2C

Up*

No

No

HNRPM

Up*

Up*

No

Coatomer protein (Copg1)

Up*

Up*

Up*

Hnrpu

No

Up*

Up*

MAP kinase kinase 3b

Up**

No

No

Hnrnpc

Up*

Up*

Up*

Protein phosphatase 1 (Ppp1cc)

No

Up*

No

Damage-specific DNA binding (Ddb1)

Up*

Up**

Up***

Na, K-ATPase β-subunit

No

Up**

Up*


The genes presented were upregulated (up) or downregulated (down) at least 2.5-fold (*2.5-fold to fourfold, ** fourfold to sixfold, *** above sixfold) and were not found in a Medline search in which the gene name and TGF-β1 were used as keywords. The genes are grouped according to their involvement in specific cellular functions.

Xie et al. Breast Cancer Res 2003 5:R187-R198   doi:10.1186/bcr640

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