Table 2 |
||||||||||
|
Proportions of probands with a germline ancestral mutation in BRCA1 or BRCA2 out of total tested (percentages in parentheses), by personal cancer history and number of first-degree relatives with breast cancer, and number of second-degree relatives with breast cancer |
||||||||||
| No. of first-degree relatives with breast cancer |
No. of second-degree relatives with breast cancer |
|||||||||
|
|
|
|||||||||
| Cancer status |
0 |
1 |
2 |
3 |
0 |
1 |
2 |
3 |
4 |
5 |
|
|
||||||||||
| No breast or ovarian cancer |
1/47 (2%) |
11/94 (12%) |
0/7 (0%) |
- |
6/77 (7%) |
5/56 (9%) |
1/14) (7% |
0/1 (0%) |
- |
- |
| Breast cancer only |
22/175 (13%) |
16/66 (24%) |
4/8 (50%) |
0/1 (0%) |
30/165 (18%) |
9/64 (14%) |
1/15 (7%) |
1/5 (20%) |
- |
1/1 (100%) |
| Ovarian cancer only |
6/17 (35%) |
1/5 (20%) |
- |
- |
5/17 (29%) |
2/4 (50%) |
- |
- |
0/1 (0%) |
- |
| Breast and ovarian cancer |
2/3 (67%) |
1/1 (100%) |
- |
- |
1/1 (100%) |
2/3 (67%) |
- |
- |
- |
- |
|
|
||||||||||
|
Apicella et al. Breast Cancer Res 2003 5:R206 doi:10.1186/bcr644 |
||||||||||
