Table 3 |
||||||
|
Proportions of probands with a germline ancestral mutation in BRCA1 or BRCA2 out of total tested (percentages in parentheses), by personal cancer history and number of first-degree relatives with ovarian cancer, and with number of second-degree relatives with ovarian cancer |
||||||
| No. of first-degree relatives with ovarian cancer |
No. of second-degree relatives with ovarian cancer |
|||||
|
|
|
|||||
| Cancer status |
0 |
1 |
2 |
0 |
1 |
2 |
|
|
||||||
| No breast or ovarian cancer |
10/131 (8%) |
8/89 (9%) |
0/7 (0%) |
11/144 (8%) |
1/4 (25%) |
- |
| Breast cancer only |
34/237 (14%) |
13/42 (31%) |
- |
38/242 (16%) |
4/5 (80%) |
0/3 (0%) |
| Ovarian cancer only |
4/18 (22%) |
3/4 (75%) |
- |
5/20 (25%) |
2/2 (100%) |
- |
| Breast and ovarian cancer |
3/3 (100%) |
0/1 (0%) |
- |
3/4 (75%) |
- |
- |
|
|
||||||
|
Apicella et al. Breast Cancer Res 2003 5:R206 doi:10.1186/bcr644 |
||||||
