Table 4 |
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|
Proportions of probands with a germline ancestral mutation in BRCA1 or BRCA2 out of total tested (percentages in parentheses), by personal cancer history and having a relative with breast cancer with given age at diagnosis, for first-degree relatives and for second-degree relatives |
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| Age at diagnosis for first-degree relatives with breast cancer |
Age at diagnosis for second-degree relatives with breast cancer |
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|
|
|
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| Cancer status |
<40 years |
40–49 years |
50–59 years |
60 years or older |
<40 years |
40–49 years |
50–59 years |
60 years or older |
|
|
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| No breast or ovarian cancer |
3/15 (20%) |
4/29 (14%) |
4/34 (12%) |
0/28 (0%) |
1/6 (17%) |
2/23 (9%) |
2/19 (11%) |
1/32 (3%) |
| Breast cancer only |
3/6 (50%) |
7/23 (30%) |
7/21 (33%) |
5/30 (17%) |
3/8 (38%) |
4/16 (25%) |
3/24 (13%) |
5/52 (10%) |
| Ovarian cancer only |
1/1 (100%) |
0/1 (0%) |
0/1 (0%) |
0/2 (0%) |
0/0 (-) |
0/2 (0%) |
2/2 (100%) |
1/3 (33%) |
| Breast and ovarian cancer |
0/0 (-) |
- |
1/1 (100%) |
- |
- |
- |
- |
- |
|
|
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|
Apicella et al. Breast Cancer Res 2003 5:R206 doi:10.1186/bcr644 |
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