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Logistic regression coefficients (β), standard errors and nominal significance levels for potentially predictive factors for an Ashkenazi Jewish woman having an ancestral mutation in BRCA1 or BRCA2, derived from multiple linear logistic regression |
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| Characteristic |
β |
Standard error |
P |
|
|
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| Baseline |
-3.767 |
0.436 |
0.001 |
| Proband breast cancer diagnosis <40 years |
2.570 |
0.523 |
0.0001 |
| Proband breast cancer diagnosis 40–49 years |
1.707 |
0.455 |
0.0002 |
| Proband breast cancer diagnosis 50–59 years |
0.493 |
0.602 |
0.4 |
| Proband breast cancer diagnosis 60+ years |
0.578 |
0.598 |
0.3 |
| Proband bilateral breast cancer at any age |
0.912 |
0.500 |
0.07 |
| Proband ovarian cancer at any age |
2.621 |
0.570 |
0.0001 |
| For each relative with cancer |
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| 1st degree, breast cancer diagnosis <40 years |
1.790 |
0.637 |
0.005 |
| 1st degree, breast cancer diagnosis 40–49 years |
1.154 |
0.438 |
0.008 |
| 1st degree, breast cancer diagnosis 50–59 years |
1.227 |
0.419 |
0.003 |
| 1st degree, breast cancer diagnosis 60+ years |
0.033 |
0.482 |
0.9 |
| 1st degree, ovarian cancer at any age |
1.339 |
0.454 |
0.003 |
| 2nd degree, breast cancer diagnosis <40 years |
0.892 |
0.591 |
0.13 |
| 2nd degree, ovarian cancer at any age |
1.004 |
0.489 |
0.04 |
| 1st or 2nd degree, bilateral breast cancer at any age |
-0.088 |
0.572 |
0.9 |
Apicella et al. Breast Cancer Res 2003 5:R206 doi:10.1186/bcr644 |
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