E-cadherin is expressed at normal levels at the metastatic foci. Distant metastases from two different primary invasive ductal carcinomas to (A) the lung and (B) the bone. Note the crisp membranous staining for E-cadherin, which is specific for the cancer cells. Fibroblasts and other stromal cells are negative. 200 × magnification.
Kowalski et al. Breast Cancer Res 2003 5:R217-R222 doi:10.1186/bcr651