Table 1

Commonly used breast cancer xenograft models

Human breast cancer xenograft model

Description

Reference

MCF-7

Breast adenocarcinoma cell line, oestrogen receptor-positive

[37]

MCF-7/6

Oestrogen sensitive

[38]

MCF-7 BAG

Immunodeficient xenograft model

[39]

MCF-7/hVEGF

hVEGF overexpressing

MCF-7-TAM LT

Long-term tamoxifen-stimulated breast tumour model

[40]

MCF-7/neu

Overexpressing oncogene neu

[41]

MCF-7-MIII

Oestrogen sensitive

[42]

MCF-7Ca

Transfected with human aromatase gene

[43]

MT2

MCF-7 tamoxifen-stimulated tumour with Asp351Tyr mutant oestrogen receptor

[44]

MT2 TAM

MCF-7-derived tumour serially passaged with tamoxifen

[40]

MT-1

Oestrogen and progesterone receptor-negative in nude rats

[45]

MT-3

Oestrogen receptor-negative

[45]

LY2

Anti-oestrogen-resistant variant of MCF-7

[46]

UMB-1Ca

Oestrogen-independent variant of MCF-7

[47]

MDA-MB-231

Oestrogen independent

[48]

MDA-MD-231 BAG

Immunodeficient xenograft model

[39]

MDA-MB-361

Brain metastasis-derived breast adenocarcinoma cell line

[49]

MDA-MB-435

Oestrogen receptor-negative

[48]

MDA-MB-435A

Ascites model

[50]

MDA-MB-435S

Spindle-shaped strain of parent line

[51]

MDA-MD-435 BAG

Immunodeficient xenograft model

[39]

MDA-MB-453 BAG

Fibroblast growth factor receptor overexpressing

[39]

MDA-453/LCC6

[52]

MDA-MB-468

Oestrogen receptor-negative metastasis-derived cell line

[49]

MDA-MB-453

Breast adenocarcinoma cell line

[53]

MCF10AT

Preneoplastic and proliferative model; nontumourigenic

[54]

MCF10AneoN

Transfected with neomycin-resistance gene

[55]

MCF10AneoT

T24-Ha-ras-transformed derivative of MCF10A

[55]

MCF10DCIS.com

Comedo ductal carcinoma in situ

[56]

MC-2

[57]

MC-5

[57]

MC-18

[57]

SK-BR3

Breast adenocarcinoma cell line that overexpresses oncogenic protein p185HER2; oestrogen receptor-negative

[58]

SK-BR3/hVEGF

VEGF overexpressing cell line

[58]

BT-20

Oestrogen receptor-negative

[37]

BT-474

Erb2 overexpressing breast tumour

[59]

ZR-75-1

Oestrogen-dependent breast carcinoma

[60]

SUM149

Inflammmatory breast cancer cell line

[61]

SUM159PT

Oestrogen independent

[62]

T47D

Oestrogen receptor-positive

[63]

T47D-E2

Tamoxifen naïve tumour

[63]

KPL-1

Oestrogen receptor-positive

[64]

KPL-4

Oestrogen receptor-negative

[65]

MaTu

Oestrogen receptor-negative solid human mammary carcinoma cell line

[45]

MC4000

Oestrogen receptor-negative

[45]

HT-39

Oestrogen receptor-negative

[66]

HX99

[67]

T61

Oestrogen receptor-positive ductal carcinoma

[68]

B37

[69]

BO

Oestrogen receptor-positive

[70]

Br10

[71]

SE

[71]

WIBC-9

Inflammmatory breast cancer cell line

[57]

Met-1

Metastatic breast cancer cell line

MAXF401

[72]

MX-1

[73]

MAXF 499

Solid ductal

[74]

NCI/ADR or MCF-7/ADR

Multidrug-resistant MCF-7 cell line that overexpresses P-glycoprotein

[75]

4296

Oestrogen receptor-positive

[76]

4049

Oestrogen receptor-negative

[76]

4151

[75]

4134

[75]

3366

[77]

4000

[77]

CAL51

Metastatic model of adenocarcinoma

[78]

MA-11

Oestrogen and progesterone negative receptor in nude rats

[79]

H31

[80]

MARY-X

Inflammatory breast cancer model

[81]

HBT 3477

Adenocarcinoma

[82]

Hs578T

Carcinosarcoma derived, epithelial in origin

[82]

C8161

Breast cancer line with high levels of spontaneous metastasis

[83]

M24met

Breast cancer line with high levels of spontaneous metastasis

[83]

CaMa 15

Primary infiltrating ductal breast carcinoma

[37]

MaNo 4

Medullary breast carcinoma

[37]

GI-101

Metastatic breast tumour line

[25]

UISO-BCA-NMT-18

Primary breast carcinoma

[84]

VEGF, vascular endothelial growth factor.

Kim et al. Breast Cancer Res 2004 6:22   doi:10.1186/bcr645