Table 2 |
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|
Most frequent differentially expressed genes between normal breast epithelium and ductal carcinoma in situ (DCIS) |
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| Tag |
Gene |
Description |
Locus link |
Fold change |
P value |
|
|
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| DCIS overexpressed genes |
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| GTATTTAACT |
PKD1-like |
Polycystic kidney disease 1-like |
79932 |
13.7 |
0.0100 |
| CGGACTCACT |
STARD10 |
START domain containing 10 |
10809 |
11.2 |
0.0086 |
| GTGTTGGGGG |
EPS8L2 |
EPS8-like 2 |
64787 |
9.6 |
0.0099 |
| TTTCTGGAGG |
KIAA0545 |
KIAA0545 protein |
23094 |
8.6 |
0.0100 |
| GATAAATTAA |
FLJ14153 |
Hypothetical protein |
64747 |
8.5 |
0.0055 |
| GAGAAATATC |
NP220 |
Nuclear protein |
27332 |
8.0 |
0.0088 |
| CCCTCTTTGG |
LOC118487 |
mRNA similar to RIKEN cDNA 1110001019 |
118487 |
7.4 |
0.0037 |
| CTGGGACTGA |
LSM4 |
U6 small nuclear RNA associated (S. cerevisiae) |
25804 |
6.4 |
0.0055 |
| CTGGGCCAGC |
VAMP5 |
Vesicle-associated membrane protein 5 |
10791 |
6.4 |
0.0068 |
| GCCCTTTCTC |
MRC2 |
Mannose receptor, C type 2 |
9902 |
5.8 |
0.0015 |
| TCTTGATTTA |
A2M |
Alpha-2-macroglobulin |
2 |
5.8 |
0.0083 |
| TAGTTTGTGG |
MSH2 |
MutS homolog 2, colon cancer |
4436 |
5.6 |
0.0091 |
| TCAGTGAACT |
HPS4 |
Hermansky–Pudlak syndrome 4 |
89781 |
5.6 |
0.0100 |
| GTTTATTCTT |
FOXA1 |
Forkhead box A1 |
3169 |
5.3 |
0.0044 |
| GCCGCTGCCA |
PPP1R13B |
Protein phosphatase 1 |
23368 |
4.3 |
0.0054 |
| TAAAGTGTCT |
PIGS |
Phosphatidylinositol glycan, class S |
94005 |
3.9 |
0.0100 |
| DCIS underexpressed genes |
|||||
| GGGACGAGTG |
TM4SF1 |
Transmembrane 4 superfamily member 1 |
4071 |
-442.6 |
0.0083 |
| TAACAGCCAG |
NFKBIA |
Nuclear factor kappa light polypeptide gene |
4792 |
-158.6 |
2.4 × 10-6 |
| CAACTAATTC |
CLU |
Clusterin |
1191 |
-63.9 |
0.0036 |
| GCCTTAACAA |
PBEF |
Pre-B-cell colony-enhancing factor |
10135 |
-44.3 |
0.0020 |
| GGGTTTTTAT |
NSEP1 |
Nuclease sensitive element binding protein 1 |
4904 |
-36.2 |
0.0001 |
| GACACGAACA |
RASD1 |
RAS, dexamethasone-induce 1 |
51655 |
-31.4 |
0.0095 |
| AAGATTGGTG |
CD9 |
CD9 antigen (p24) |
928 |
-29.6 |
0.0003 |
| ACCAAATTAA |
TNFRSF10B |
Tumor necrosis factor receptor superfamily |
8795 |
-29.4 |
0.0003 |
| CTGGGCCTGA |
LITAF |
Lipopolysaccharide-induced tumor necrosis factor |
9516 |
-28.9 |
0.0076 |
| CTGCCATAAC |
SBDS |
Shwachman–Bodian–Diamond syndrome |
51119 |
-24.2 |
0.0005 |
| CACAGGCAAA |
BZW1 |
Basic leucine zipper and W2 domains 1 |
9689 |
-22.1 |
0.0056 |
| GTTCCCTGGC |
FAU |
Finkel–Biskis–Reilly murine sarcoma virus |
2197 |
-22.1 |
0.0028 |
| GTCTGCACCT |
DKFZp547C1 |
Hypothetical protein |
254851 |
-21.9 |
0.0087 |
| TACGTTGCAG |
GC20 |
Translocation factor sui1 homolog |
10289 |
-21.8 |
0.0079 |
| TGTAAAGATT |
CCNL1 |
Cyclin L1 |
57018 |
-21.2 |
0.0008 |
| TGTTAAGTTC |
CRY1 |
Cryptochrome 1 (photolyase-like) |
1407 |
-18.7 |
0.0091 |
| GAAATAAAGT |
FLJ21657 |
Hypothetical protein |
64417 |
-18.5 |
0.0032 |
| ATGGGCTTGA |
SQRDL |
Sulfide quinone reductase-like (yeast) |
58472 |
-17.3 |
0.0061 |
| TCAAGAAATT |
PSME3 |
Proteasome activator subunit 3 |
10197 |
-15.7 |
0.0028 |
| CCGTGGTCGT |
FBL |
Fibrillarin |
2091 |
-15.3 |
0.0100 |
| TGGAACAGGA |
TGIF |
Transforming growth factor beta-induced factor (TALE family homeobox) |
7050 |
-12.2 |
0.0030 |
| AATGCTGGCA |
DNAJB6 |
DnaJ homolog, subfamily B, member 6 |
10049 |
-11.7 |
0.0065 |
| AATGAGCAAC |
GBP2 |
Guanylate binding protein 2, interferon-inducible |
2634 |
-11.1 |
0.0082 |
| GACCTATCTC |
KIAA0992 |
Paladin |
23022 |
-10.9 |
0.0092 |
| AACTCTTGAA |
EIF3S3 |
Eukaryotic translation initiation factor 3 |
8667 |
-10.6 |
0.0082 |
| GGGATTTTGT |
PMAIP1 |
Phorbol-12-myristate-13-acetate-induced protein 1 |
5366 |
-10.6 |
0.0091 |
| AAAGCAAAAA |
PTPN4 |
Protein tyrosine phosphatase, non-receptor type 4 |
5775 |
-10.4 |
0.0040 |
| ACTGACTATC |
NEU1 |
Sialidase 1 (lysosomal sialidase) |
4758 |
-10.3 |
0.0095 |
| TTCCAGTTCA |
PDE4B |
Phosphodiesterase 4B, camp-specific |
5142 |
-9.9 |
0.0087 |
| GAATGATTTC |
ORF1-FL49 |
Putative nuclear protein |
84418 |
-9.5 |
0.0070 |
| GACTCGCTCC |
HSJ001348 |
cDNA for differentially expressed CO16 gene |
54742 |
-9.5 |
0.0072 |
| TGGTTACAAA |
NDEL1 |
Nude nuclear distribution gene E homolog like 1 |
81565 |
-8.9 |
0.0100 |
| AGTATGAGGA |
TNFAIP3 |
Tumor necrosis factor, alpha-induced protein 3 |
7128 |
-8.1 |
0.0083 |
| CAGTTTAAAA |
CRSP6 |
Cofactor required for Sp1 transcriptional activation |
9440 |
-7.7 |
0.0100 |
|
|
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|
Abba et al. Breast Cancer Res 2004 6:R499 doi:10.1186/bcr899 |
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