Table 3

Most frequent differentially expressed genes between ductal carcinoma in situ and invasive ductal carcinoma (IDC)

     Tag
Gene
Description
Locus link
Fold change
P value

IDC overexpressed genes
     TGGAAATGAC
COL1A1
Collagen type I, alpha 1
1277
315.4
0.0054
     ATGTGAAGAG
SPARC
Secreted protein, cysteine-rich (osteonectin)
6678
286.8
0.0003
     TTTGGTTTTC
COL1A2
Collagen type I, alpha 2
1278
210.9
0.0084
     TTGCTGACTT
COL6A1
Collagen type VI, alpha 1
1291
73.9
0.0023
     TTATGTTTAA
LUM
Lumican
4060
56.7
0.0011
     TTGGAGATCT
NDUFA4
NADH dehydrogenase (ubiquinone)
4697
56.4
0.0065
     CCACAGGGGA
COL3A1
Collagen type III, alpha 1
1281
49.4
0.0056
     ATCTTGTTAC
FN1
Fibronectin 1
2335
44.3
0.0031
     TTGTAATCGT
OAZ1
Ornithine decarboxylase antizyme 1
4946
38.6
0.0038
     TGTAATCAAT
HNRPA1
Heterogeneous nuclear ribonucleoprotein A1
3178
38.2
0.0039
     GGAAGCTAAG
OSF-2
Osteoblast specific factor 2 (fasciclin I-like)
10631
36.3
0.0005
     ACCTGTATCC
IFITM3
Interferon induced transmembrane protein 3
10410
34.3
0.0021
     GGAAATGTCA
MMP2
Matrix metalloproteinase 2
4313
29.1
0.0008
     TGCACTTCAA
SPARCL1
SPARC-like 1 (mast9, hevin)
8404
21.7
0.0050
     GGAACTTTTA
SULF2
Sulfatase 2
55959
19.8
0.0017
     CTGTTAGTGT
MDH1
Malate dehydrogenase 1
4190
18.5
0.0026
     TATGAATGCT
CSPG2
Chondroitin sulfate proteoglycan 2 (versican)
1462
18.2
0.0017
     TCCAAATCGA
VIM
Vimentin
7431
17.7
0.0014
     TGTAGTTTGA
SKP1A
S-phase kinase-associated protein 1A
6500
16.9
0.0013
     TAATAAACAG
ASAH1
n-Acylsphimgosine amidohydrolase
427
16.8
0.0085
     GCCTCCTCCC
EIF3k
Eukaryotic translation initiation factor 3
27335
16.8
0.0098
     GAAACAAGAT
PGK1
Phosphoglycerate kinase 1
5230
15.8
0.0006
     TGCTTTGGGA
TTC11
tetratricopeptide repeat domain 11
51024
15.8
0.0018
     GAAATCAAAA
SIGLEC5
Sialic acid binding Ig-like lectin 5
8778
14.7
0.0098
     ATGTAGTAGT
HNRPD
Heterogeneous nuclear ribonucleoprotein D
3184
14.7
0.0025
     GACCACCTTT
MFAP2
Microfibrillar-associated protein 2
4237
14.4
0.0000
     ACTTATTATG
DCN
Decorin
1634
13.9
0.0007
     TCTCTACCCA
APLP2
Amyloid beta (A4) precursor-like protein 2
334
13.7
0.0076
     TGCAATATGC
FBN1
Fibrillin 1
2200
13.5
0.0037
     ATTTCTTCAA
SFRP2
Secreted frizzled-related protein 2
6423
13.4
0.0030
     ATAAAAAGAA
CTSK
Cathepsin K (pycnodysostosis)
1513
13.0
0.0003
     GTACATTGTA
MGC15737
Hypothetical protein
85012
12.6
0.0011
     TGATGTTTGA
DAZAP2
DAZ associated protein 2
9802
12.5
0.0013
     TCCGTGGTTG
BASP1
Membrane attached signal protein 1
10409
12.1
0.0055
     ACTGCTTTAC
DKFZp564I1922
Adlican
25878
12.0
0.0086
     TCTGCAATGA
TINP1
Trasnforming growth factor beta-inducible nuclear protein 1
10412
12.0
0.0033
     GTTTCTTCCC
SELH
Selenoprotein H
2880636
11.8
0.0037
     AATATGCTTT
ATP6V1E1
ATPase
529
11.6
0.0009
     TTATGGATCT
SPON2
Spondin 2, extracellular matrix protein
10417
11.3
0.0003
     AAAATAAAGA
APEX1
Nuclease, multifunctional DNA repair enzyme
328
11.3
0.0099
     TGTGTGTTTG
HIF0
H1 histone family
3005
11.2
0.0029
     TATGTTTCAG
PTPN12
Protein tyrosine phosphatase
5782
11.1
0.0003
     ACCAAAGCCC
MGC9651
Hypothetical protein
114932
10.6
0.0075
     CAAGGATCTA
NICE-3
NICE-3 protein
25912
10.5
0.0057
     GACGTCTTAA
PSMA4
Proteasome subunit, alpha type
5685
10.3
0.0038
     CAGATAACAT
TOMM20
Translocase
9804
10.1
0.0064
     AACTCTTGAA
EIF3S3
Eukaryotic translation initiation factor 3
8667
10.0
0.0047
     TTCTTGGTGT
TRPS1
Trichorhinophalangeal syndrome I
7227
9.9
0.0042
     TGCCTTAGTA
DNAJC1
DNAJ homolog
64215
9.8
0.0040
     AGACAAGCTG
SFRS5
Splicing factor
6430
9.4
0.0015
     ACAAGAATTG
SYPL
Synaptophysin-like protein
6856
9.3
0.0027
     TACATCCGAA
MTPN
Myotrophin
136319
9.3
0.0013

Abba et al. Breast Cancer Res 2004 6:R499   doi:10.1186/bcr899