Table 2

Association of CHEK2 variants with breast cancer risk

CHEK2 statusa
Cases (n = 506)
Controls (n = 459)
ORb
95% CI





n
%
n
%



1100del C






     Noncarrier
499
98.8
456
99.6
1.0
Reference
     Carrier
6
1.2
2
0.4
2.9
(0.6–14.6)
R145W






     Noncarrier
505
99.8
459
100.0
1.0
Reference
     Carrier
1
0.2
0
-
-
-
I175T






     Noncarrier
504
99.6
455
99.1
1.0
Reference
     Carrier
2
0.4
4
0.9
0.5
(0.1–2.6)

aAll carriers are heterozygous. bAdjusted for age at reference and reference year. CI, confidence interval; OR, odds ratio.

Friedrichsen et al. Breast Cancer Res 2004 6:R629   doi:10.1186/bcr933