Table 3 |
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|
Frequency of CHEK2 variants in cases and controls according to age and family history features |
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|
Characteristic |
All women |
1100delC+ |
I175T+ |
|||||||||||
|
|
||||||||||||||
|
Cases |
Controls |
Cases |
Controls |
Cases |
Controls |
|||||||||
|
|
||||||||||||||
|
n |
n |
n |
% |
95% CI |
n |
% |
95% CI |
n |
% |
95% CI |
n |
% |
95% CI |
|
|
|
||||||||||||||
|
Age (years) |
||||||||||||||
|
< 30 |
10 |
16 |
0 |
0 |
0 |
0 |
||||||||
|
30–34 |
52 |
64 |
0 |
0 |
0 |
1 |
1.6 |
0.04–8.4 |
||||||
|
35–39 |
156 |
140 |
1 |
0.6 |
0.02–3.5 |
1 |
0.7 |
0.02–3.9 |
1 |
0.6 |
0.02–3.5 |
0 |
||
|
40–44 |
288 |
239 |
5 |
1.7 |
0.6–4.0 |
1 |
0.4 |
0.01–2.3 |
1 |
0.3 |
0.009–1.9 |
3 |
1.3 |
0.3–3.6 |
|
Family History of breast cancera |
||||||||||||||
|
None |
280 |
294 |
2 |
0.7 |
0.09–2.6 |
1 |
0.3 |
0.009–1.9 |
1 |
0.4 |
0.009–2.0 |
3 |
1.0 |
0.2–3.0 |
|
First-degree |
94 |
36 |
4 |
4.3 |
1.2–10.5 |
0 |
1 |
1.1 |
0.03–5.8 |
0 |
||||
|
Second-degree only |
120 |
115 |
0 |
1 |
0.9 |
0.02–4.7 |
0 |
1 |
0.9 |
0.02–4.7 |
||||
|
Number of relatives with breast cancera |
||||||||||||||
|
None |
280 |
294 |
2 |
0.7 |
0.09–2.6 |
1 |
0.3 |
0.009–1.9 |
1 |
0.4 |
0.009–2.0 |
3 |
1.0 |
0.2–3.0 |
|
1 |
137 |
114 |
3 |
2.2 |
0.5–6.3 |
1 |
0.9 |
0.02–4.8 |
1 |
0.7 |
0.02–4.0 |
0 |
||
|
2 |
51 |
29 |
1 |
2.0 |
0.05–10.4 |
0 |
0 |
1 |
3.4 |
0.09–17.8 |
||||
|
3+ |
26 |
8 |
0 |
0 |
0 |
0 |
||||||||
|
Family history of ovarian cancer |
||||||||||||||
|
None |
461 |
432 |
4 |
0.9 |
0.2–2.2 |
2 |
0.5 |
0.06–1.7 |
2 |
0.4 |
0.05–1.6 |
4 |
0.9 |
0.3–2.4 |
|
1st or 2nd degree |
45 |
27 |
2 |
4.4 |
0.5–15.1 |
0 |
0 |
0 |
||||||
|
Family history of breast and/or ovarian cancera |
||||||||||||||
|
No breast/no ovarian |
258 |
278 |
2 |
0.8 |
0.09–2.8 |
1 |
0.4 |
0.009–2.0 |
1 |
0.4 |
0.01–2.1 |
3 |
1.1 |
0.2–3.1 |
|
No breast/yes ovarian |
22 |
16 |
0 |
0 |
0 |
0 |
||||||||
|
Yes breast/no ovarian |
192 |
141 |
2 |
1.0 |
0.1–3.7 |
1 |
0.7 |
0.02–3.9 |
1 |
0.5 |
0.01–2.9 |
1 |
0.7 |
0.02–3.9 |
|
Yes breast/yes ovarian |
22 |
10 |
2 |
9.1 |
1.1–29.2 |
0 |
0 |
0 |
||||||
|
|
||||||||||||||
|
aTwelve cases and 14 controls had missing information on their family history and are excluded. There were no CHEK2 variants in these women. |
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|
Friedrichsen et al. Breast Cancer Res 2004 6:R629 doi:10.1186/bcr933 |
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