Table 3

Frequency of CHEK2 variants in cases and controls according to age and family history features
Characteristic
 All women
 1100delC+
 I175T+


Cases
 Controls
 Cases
 Controls
 Cases
 Controls


n
 n
 n
 %
 95% CI
 n
 %
 95% CI
 n
 %
 95% CI
 n
 %
 95% CI
Age (years)
< 30
 10
 16
 0

0

0

0

     30–34
 52
 64
 0

0

0

1
 1.6
 0.04–8.4
     35–39
 156
 140
 1
 0.6
 0.02–3.5
 1
 0.7
 0.02–3.9
 1
 0.6
 0.02–3.5
 0

     40–44
 288
 239
 5
 1.7
 0.6–4.0
 1
 0.4
 0.01–2.3
 1
 0.3
 0.009–1.9
 3
 1.3
 0.3–3.6
Family History of breast cancera
     None
 280
 294
 2
 0.7
 0.09–2.6
 1
 0.3
 0.009–1.9
 1
 0.4
 0.009–2.0
 3
 1.0
 0.2–3.0
     First-degree
 94
 36
 4
 4.3
 1.2–10.5
 0

1
 1.1
 0.03–5.8
 0

     Second-degree only
 120
 115
 0

1
 0.9
 0.02–4.7
 0

1
 0.9
 0.02–4.7
Number of relatives with breast cancera
     None
 280
 294
 2
 0.7
 0.09–2.6
 1
 0.3
 0.009–1.9
 1
 0.4
 0.009–2.0
 3
 1.0
 0.2–3.0
     1
 137
 114
 3
 2.2
 0.5–6.3
 1
 0.9
 0.02–4.8
 1
 0.7
 0.02–4.0
 0

     2
 51
 29
 1
 2.0
 0.05–10.4
 0

0

1
 3.4
 0.09–17.8
     3+
 26
 8
 0

0

0

0

Family history of ovarian cancer
     None
 461
 432
 4
 0.9
 0.2–2.2
 2
 0.5
 0.06–1.7
 2
 0.4
 0.05–1.6
 4
 0.9
 0.3–2.4
     1st or 2nd degree
 45
 27
 2
 4.4
 0.5–15.1
 0

0

0

Family history of breast and/or ovarian cancera
     No breast/no ovarian
 258
 278
 2
 0.8
 0.09–2.8
 1
 0.4
 0.009–2.0
 1
 0.4
 0.01–2.1
 3
 1.1
 0.2–3.1
     No breast/yes ovarian
 22
 16
 0

0

0

0

     Yes breast/no ovarian
 192
 141
 2
 1.0
 0.1–3.7
 1
 0.7
 0.02–3.9
 1
 0.5
 0.01–2.9
 1
 0.7
 0.02–3.9
     Yes breast/yes ovarian
 22
 10
 2
 9.1
 1.1–29.2
 0

0

0

aTwelve cases and 14 controls had missing information on their family history and are excluded. There were no CHEK2 variants in these women.

Friedrichsen et al. Breast Cancer Res 2004 6:R629   doi:10.1186/bcr933

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