Table 1

Association between the progesterone receptor exon 4 (Val660→Leu) G/T polymorphism and breast cancer risk

Genotype^a

Cases, n (%)

Controls, n (%)

Crude OR (95% CI)

Adjusted OR (95 % CI)

G/G (Val/Val)

869 (69)

1186 (71)

1.0^b

1.0^c

G/T+T/T(Val/Leu+Leu/Leu)

383 (31)

474 (29)

1.08 (0.92–1.27)

1.10 (0.93–1.30)

Premenopausal women

G/G(Val/Val)

68 (65)

79 (72)

1.0^d

1.0^e

G/T+T/T(Val/Leu+Leu/Leu)

36 (35)

31 (28)

1.35 (0.75–2.41)

1.21 (0.64–2.28)

Postmenopausal women

G/G(Val/Val)

745 (69)

1044 (71)

1.0^f

1.0^g

G/T+T/T(Val/Leu+Leu/Leu)

330 (31)

427 (29)

1.09 (0.92–1.29)

1.08 (0.91–1.28)

^aNumbers may vary because of missing genotypes.

^bConditional logistic regression adjusted for the following matching variables: age, menopausal status, postmenopausal hormone use at blood draw, date at blood draw, time at blood draw, and fasting status.

^cConditional logistic regression adjusted for matching variables and age at menarche, age at menopause, age at first birth/parity, Body Mass Index (BMI) at age 18 years, weight gain since age 18 years, benign breast disease, first-degree family history of breast cancer, and duration of postmenopausal hormone use.

^dUnconditional logistic regression adjusted for matching variables listed in footnote b.

^eUnconditional logistic regression adjusted for matching variables in footnote b and other covariates listed in footnote c.

^fUnconditional logistic regression adjusted for the following matching variables: age, menopausal status, postmenopausal use at blood draw, date at blood draw, time at blood draw, and fasting status.

^gUnconditional logistic regression adjusted for matching variables in footnote f and age at menarche, age at first birth/parity, BMI at age 18 years, weight gain since age 18 years, benign breast disease, first-degree family history of breast cancer, and duration of postmenopausal hormone use.

De Vivo et al. Breast Cancer Res 2004 6:R636   doi:10.1186/bcr928