Figure 4.

Inhibition of spontaneous tumor formation by vaccination with virus-like replicon particles (VRP)-neu. Groups of MMTV-c-neu transgenic mice (n = 10 per group) were vaccinated three times (▼) at 2-week intervals with 10⁶ IU VRP-neu (▲) or 10⁶ IU VRP-hemagglutinin (HA) (■). The mice vaccinated with VRP-HA were killed when moribund, and the mice vaccinated with VRP-neu were killed at 240 days.