Table 3

Risk associated with AR CAG repeat length amongst BRCA2 mutation carriers

Risk allele

Adjusted group, ethnicity

Adjusted group, ethnicity and additional variables

P

RR (95% CI)

P

RR (95% CI)

AR ≥ 28 CAG

0.8

1.12 (0.55–2.25)

0.9

1.04 (0.47–2.32)

AR ≥ 29 CAG

0.8

0.88 (0.37–2.09)

0.8

0.90 (0.32–2.52)

AR average CAG

0.7

0.98 (0.91–1.06)

1.0

1.00 (0.92–1.09)

AR small CAG

0.6

0.98 (0.90–1.06)

1.0

1.00 (0.92–1.09)

AR large CAG

0.9

0.99 (0.93–1.06)

1.0

1.00 (0.93–1.07)

First primary breast cancer diagnosis was considered an event (status affected), whereas first primary ovarian cancers were censored as unaffected at age of diagnosis, and individuals without breast or ovarian cancer were censored as unaffected at age at interview. All individuals were censored as unaffected at age of prophylactic mastectomy before diagnosis/interview. Analyses were adjusted for source group, ethnicity, year of birth, and hormonal variables oophorectomy, parity, age at menarche, and contraceptive pill use. Oophorectomy and parity were treated as time-dependent variables from age at first variable event. Analyses were conducted using unweighted Cox regression.

Spurdle et al. Breast Cancer Res 2005 7:R176   doi:10.1186/bcr971