|
Proportional hazards regression model: hazard ratio and 95% confidence interval (CI) for mastectomy-treated breast cancer patients in the Surveillance, Epidemiology, and End Results (SEER) Breast Implant Surveillance Study, 1983–1989 (n = 4385)a |
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| Covariate |
Distribution of sample |
Breast cancer mortality |
Non-breast cancer mortality |
|||
|
|
||||||
| n |
% |
Hazard ratio |
95% confidence interval |
Hazard ratio |
95% confidence interval |
|
|
|
||||||
| Implant status |
||||||
| No (referent) |
3568 |
81.4 |
1.00 |
- |
1.00 |
- |
| Yes |
817 |
18.6 |
0.54 |
0.43–0.67 |
0.59 |
0.41–0.85 |
| Age at diagnosis |
||||||
| < 35 years |
163 |
3.7 |
1.95 |
1.42–2.69 |
0.24 |
0.09–0.66 |
| 35–44 years |
805 |
18.4 |
1.29 |
1.07–1.56 |
0.19 |
0.12–0.30 |
| 45–54 years |
1332 |
30.4 |
1.02 |
0.86–1.20 |
0.35 |
0.26–0.46 |
| 55–64 years (referent) |
2085 |
47.6 |
1.00 |
- |
- |
- |
| Race/ethnicity |
||||||
| Non-Hispanic White (referent) |
3915 |
89.3 |
1.00 |
- |
1.00 |
- |
| Non-Hispanic Black |
131 |
3.0 |
0.90 |
0.58–1.39 |
1.58 |
0.93–2.68 |
| Hispanic |
120 |
2.7 |
1.37 |
0.93–2.04 |
1.22 |
0.64–2.33 |
| Non-Hispanic Asian |
160 |
3.7 |
0.86 |
0.57–1.31 |
0.68 |
0.33–1.39 |
| Other/unknown |
59 |
1.4 |
0.75 |
0.37–1.50 |
1.36 |
0.60–3.07 |
| Stage at diagnosis |
||||||
| Local (referent) |
3126 |
71.3 |
1.00 |
- |
1.00 |
- |
| Regional |
1208 |
27.6 |
2.28 |
1.97–2.63 |
1.86 |
1.65–2.09 |
| Unstaged |
51 |
1.2 |
3.80 |
2.41–5.99 |
3.35 |
2.28–4.92 |
| SEER region |
||||||
| San Francisco–Oakland (referent) |
1624 |
37.0 |
1.00 |
- |
1.00 |
- |
| Seattle–Puget Sound |
1423 |
34.1 |
1.10 |
0.91–1.32 |
1.17 |
0.91–1.51 |
| Iowa |
1268 |
28.9 |
1.15 |
0.96–1.38 |
0.86 |
0.66–1.13 |
| Year of diagnosis |
||||||
| 1983 (referent) |
1037 |
23.7 |
1.00 |
- |
1.00 |
- |
| 1985 |
1003 |
22.9 |
1.06 |
0.88–1.29 |
0.96 |
0.73–1.27 |
| 1987 |
1232 |
28.1 |
0.97 |
0.80–1.18 |
1.05 |
0.78–1.40 |
| 1989 |
1113 |
25.4 |
0.84 |
0.68–1.04 |
1.12 |
0.80–1.56 |
| Grade |
||||||
| Well differentiated (referent) |
142 |
3.2 |
1.00 |
- |
1.00 |
- |
| Moderately differentiated |
695 |
15.9 |
2.16 |
1.13–4.13 |
0.75 |
0.42–1.34 |
| Poorly differentiated |
817 |
18.6 |
3.45 |
1.82–6.53 |
0.79 |
0.44–1.40 |
| Undifferentiated |
182 |
4.2 |
4.97 |
2.52–9.78 |
1.23 |
0.60–2.52 |
| Unknown |
2549 |
58.1 |
2.41 |
1.28–4.52 |
0.85 |
0.50–1.45 |
| Histology |
||||||
| Ductal (referent) |
3253 |
74.2 |
1.00 |
- |
1.00 |
- |
| Lobular |
279 |
6.4 |
1.09 |
0.82–1.44 |
1.26 |
0.88–1.81 |
| Mixed ductal and lobular |
167 |
3.8 |
1.06 |
0.74–1.53 |
0.66 |
0.32–1.33 |
| Other |
686 |
15.6 |
0.71 |
0.57–0.89 |
1.01 |
0.76–1.34 |
| Radiation therapy |
||||||
| No (referent) |
4047 |
92.3 |
1.00 |
- |
1.00 |
- |
| Yes |
329 |
7.5 |
1.43 |
1.15–1.78 |
0.84 |
0.54–1.30 |
| Unknown |
9 |
0.2 |
4.68 |
1.74–12.60 |
- |
- |
| Type of breast implantb |
||||||
| Silicone gel (referent) |
274 |
39.8 |
1.00 |
- |
1.00 |
- |
| Saline |
118 |
17.1 |
1.01 |
0.44–2.34 |
1.75 |
0.29–10.39 |
| Double lumen |
240 |
34.8 |
1.49 |
0.83–2.70 |
3.13 |
0.91–10.78 |
| Other |
26 |
3.8 |
1.11 |
0.24–5.03 |
- |
- |
| Unknown |
31 |
4.5 |
2.03 |
0.71–5.79 |
6.59 |
1.17–37.06 |
|
aAdjusted for age, year, stage at diagnosis, race/ethnicity, SEER region, tumor grade, histology, and radiation therapy. bModel (n = 689) restricted to women with implant-specific information and concordant bilateral implants | ||||||
Le et al. Breast Cancer Res 2005 7:R184 doi:10.1186/bcr974 |
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