Table 1

RNAi directed against c-Myc significantly inhibits MCF-7 cell growth in nude mice

No. of cellsa
pSilencer
pSilencer–c-Myc



Tumor weight (mg)
Tumors
Injections
Latencyb (day)
Tumor weight (mg)
Tumors
Injections
Latencyb (day)

106
45–210
3
5
42–49
0
0
5
>56
2 × 106
145–2248
4
5
21–28
0
0
5
>35

aNumber of cells transfected with the indicated plasmids that were injected subcutaneously, bilaterally into five nude mice.

bThe time interval required for a palpable tumor to arise.

Wang et al. Breast Cancer Res 2005 7:R220   doi:10.1186/bcr975

Open Data