Table 2

Myofibroblast-related genes that are differentially upregulated in fibroblasts activated by serum compared with serum-starved fibroblasts

Gene symbol
Gene name
Fold increase in signal intensity in serum-activated fibroblasts versus serum depleted fibroblasts (P < 0.001)

LOXL2
Lysyl oxidase-like 2
8.2
PLOD2
Procollagen-lysine, 2 oxoglutarate 5-dioxygenase
16
PLAUR
Plasminogen activator urokinase receptor
5.3
TAGLN
Transgelin
6.0
TPM2
Tropomysin 2 (beta)
4.6
MYL6
Myosin, light polypeptide 6, alkaline, smooth muscle
5.7
TFPI2
Tissue factor pathway inhibitor 2
4.8
SMAD3
Mothers against decapentaplegic homolog 3 (Drosophila)
4.0
CXCL12
Chemokine (C-X-C motif) ligand 12
4.5
TGFB1
TGF-β, induced
26.5
LTBP2
Latent TGF-β binding protein 2
30.2
COX2
Cyclo-oxygenase-2
16.4
CLIC4
Chloride intracellular channel 4
32

TGF, transforming growth factor.

Samoszuk et al. Breast Cancer Research 2005 7:R274   doi:10.1186/bcr995