Table 1 |
||
|
Participation of mAchR subtypes in angiogenesis induced by TMps |
||
| Treatment |
Angiogenic response (vessels/mm2) |
n |
|
|
||
| None |
2.33 ± 0.07 |
5 |
| CARB |
4.98 ± 0.40** |
5 |
| AT + CARB |
2.57 ± 0.25 |
5 |
| PIR + CARB |
2.49 ± 0.63 |
4 |
| MET + CARB |
3.35 ± 0.17* |
5 |
| 4-DAMP + CARB |
2.64 ± 0.48 |
6 |
|
|
||
|
Peritoneal macrophages (3 × 105) from 7-day LMM3 tumor-bearing mice (TMps) untreated or stimulated with carbachol (CARB; 100 nM) in the absence or presence of 1 μM atropine (AT), pirenzepine (PIR), methoctramine (MET) or 4-diphenylacetoxy-N-methylpiperidine (4-DAMP) were inoculated intradermally into normal mice to evaluate the angiogenic response. **P < 0.0001, *P < 0.05 compared with untreated TMps (Mann–Whitney test). n, number of sites evaluated. Results are means ± SEM for three experiments. |
||
|
de la Torre et al. Breast Cancer Research 2005 7:R345 doi:10.1186/bcr1005 |
||
