Table 2 |
||
|
Participation of arginase and COX in angiogenesis induced by TMps |
||
| Treatment |
Angiogenic response (vessels/mm2) |
n |
|
|
||
| None |
2.34 ± 0.06 |
5 |
| CARB |
4.96 ± 0.41* |
5 |
| NOHA + CARB |
2.4 ± 0.6 |
4 |
| INDO + CARB |
1.9 ± 0.92 |
8 |
| NS-398 + CARB |
1.3 ± 0.31 |
5 |
|
|
||
|
Peritoneal macrophages (3 × 105) from 7-day LMM3 tumor-bearing mice (TMps) stimulated with carbachol (CARB; 100 nM) in the absence or presence of Nω-hydroxy-L-arginine (NOHA; 100 μM), indomethacin (INDO; 1 μM) or NS-398 (10 μM) were inoculated intradermally into normal mice to evaluate the angiogenic response. *P < 0.001 compared with control (without treatment) (Mann–Whitney test). n, number of sites evaluated. Results are means ± SEM for three experiments. |
||
|
de la Torre et al. Breast Cancer Research 2005 7:R345 doi:10.1186/bcr1005 |
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