Prognostic impact of topoisomerase IIα protein expression with regard to stage and grading. Patients with tumors positive for topoisomerase IIα in more than 25% of tumor cells (solid lines) were compared with those having tumors expressing topoisomerase IIα in less than 25% of cells (dashed lines) with regard to the stage (a) and the grading (b) of the tumor. The difference was significant in tumors of stage 2 and 3 (P < 0.05) and in grade 2 and 3 tumors (P < 0.05).
Fritz et al. Breast Cancer Research 2005 7:R374-R384 doi:10.1186/bcr1012