Table 5 |
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|
Association between some potential risk factors of breast cancer by CYP17 genotype among premenopausal women in Germany |
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|
Factor |
All data |
A1/A1 |
A1/A2 and A2/A2 |
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|
|
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|
Cases (n = 527) |
Controls (n = 904) |
ORa (95% CI) |
Cases (n = 180) |
Controls (n = 323) |
ORa (95% CI) |
Cases (n = 347) |
Controls (n = 581) |
ORa (95% CI) |
|
|
|
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|
Age at menarcheb |
|||||||||
|
<13 years |
186 |
323 |
1.00 |
68 |
123 |
1.00 |
118 |
200 |
1.00 |
|
≥13 years |
338 |
580 |
1.00 (0.80–1.27) |
112 |
199 |
1.01 (0.67–1.51) |
226 |
381 |
1.00 (0.75–1.34) |
|
Age at menarche, nulliparous women |
|||||||||
|
<13 years |
43 |
64 |
1.00 |
17 |
24 |
1.00 |
26 |
40 |
1.00 |
|
≥13 years |
79 |
135 |
0.79 (0.48–1.31) |
24 |
46 |
0.98 (0.38–2.55) |
55 |
89 |
0.91 (0.47–1.78) |
|
Age at menarche, parous women |
|||||||||
|
<13 years |
143 |
259 |
1.00 |
51 |
99 |
1.00 |
92 |
160 |
1.00 |
|
≥13 years |
259 |
445 |
1.11 (0.85–1.45) |
88 |
153 |
1.08 (0.68–1.72) |
171 |
292 |
1.09 (0.78–1.53) |
|
Pill usec |
|||||||||
|
Never |
85 |
178 |
1.00 |
30 |
62 |
1.00 |
55 |
116 |
1.00 |
|
Ever |
442 |
724 |
1.23 (0.91–1.66) |
150 |
260 |
1.22 (0.72–2.09) |
292 |
464 |
1.24 (0.86–1.79) |
|
Pill use, nulliparous women |
|||||||||
|
Never |
25 |
48 |
1.00 |
10 |
23 |
1.00 |
15 |
25 |
1.00 |
|
Ever |
99 |
150 |
1.64 (0.87–3.08) |
31 |
46 |
2.60 (0.81–8.43) |
68 |
104 |
1.35 (0.59–3.10) |
|
Pill use, parous women |
|||||||||
|
Never |
60 |
130 |
1.00 |
20 |
39 |
1.00 |
40 |
91 |
1.00 |
|
Ever |
343 |
574 |
1.26 (0.89–1.80) |
119 |
214 |
1.10 (0.58–2.09) |
224 |
360 |
1.35 (0.88–2.05) |
|
Age at first full-term preganancyd |
|||||||||
|
<25 years |
215 |
352 |
1.00 |
69 |
125 |
1.00 |
146 |
227 |
1.00 |
|
≥25 years |
188 |
353 |
0.86 (0.66–1.14) |
70 |
128 |
0.98 (0.60–1.59) |
118 |
225 |
0.79 (0.56–1.11) |
|
Breastfeeding statusd |
|||||||||
|
Never |
116 |
187 |
1.00 |
43 |
65 |
1.00 |
73 |
122 |
1.00 |
|
Ever |
287 |
518 |
0.90 (0.68–1.20) |
96 |
188 |
0.70 (0.43–1.16) |
191 |
330 |
1.02 (0.71–1.46) |
|
Total months of breastfeeding among parous ever breastfed women |
|||||||||
|
1–12 |
253 |
416 |
1.00 |
86 |
156 |
1.00 |
167 |
260 |
1.00 |
|
>12 |
34 |
102 |
0.56 (0.36–0.87) |
10 |
32 |
0.69 (0.30–1.60) |
24 |
70 |
0.53 (0.31–0.90) |
|
|
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|
aMultivariate adjusted odds ratio (OR) and 95% confidence interval (CI). Adjusted for alcohol consumption (0, 1 to 18, >18 g/day); current body mass index as continuous variable; educational level (low, middle, high); family history of breast cancer in first-degree relative (no, yes); parity (0, 1 to 2 births, 3+ births), and other variables in the table where appropriate. bThree cases and one control had missing data. cTwo controls had missing data. dLimited to parous women. |
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|
Verla-Tebit et al. Breast Cancer Research 2005 7:R455 doi:10.1186/bcr1027 |
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