Table 3

Effect of category of benign breast disease histology on breast cancer riska

Benign breast disease category
Cases No. (%)
Controls No. (%)
OR (95% CI)b
OR (95% CI)c

Nonproliferative
69(24.5)
474 (38.8)
1.00 (Ref)
1.00 (Ref)
Proliferative without atypia
140 (49.7)
623 (50.9)
1.59 (1.16–2.18)
1.54 (1.12–2.11)
Atypical hyperplasia
73 (25.9)
126 (10.3)
4.54 (3.03–6.78)
4.43 (2.93–6.69)
Total
282
1,223



aNurses' Health Study I (1976 to 1994) and II (1989 to 1995). bAdjusted for age, year of biopsy, and follow-up interval. cAdjusted for age, year of biopsy, and follow-up interval, age at menarche, body mass index, weight change since age 18, age at first birth/parity, menopausal status/type of menopause, duration of postmenopausal hormone use. CI, confidence interval; OR, odds ratio; Ref, reference group for statistical comparisons.

Tamimi et al. Breast Cancer Research 2005 7:R555   doi:10.1186/bcr1039

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