Table 4

Combined effect of alcohol and category of benign breast disease histology on breast cancer riska




Jointly-classifiedb
 Stratifiedc>
Category of BBD
 Recent alcohol consumption (g/day)
 Cases
 Controls
 OR (95% CI)d
 OR (95% CI)e
 OR (95% CI)d
 OR (95% CI)e
Nonproliferative







0
 21
 178
 1.00 (Ref)
 1.00 (Ref)
 1.00 (Ref)
 1.00 (Ref)

<5
 27
 165
 1.41 (0.76–2.60)
 1.42 (0.77–2.65)
 1.34 (0.72–2.50)
 1.46 (0.75–2.85)

5–15
 14
 95
 1.27 (0.62–2.62)
 1.25 (0.60–2.60)
 1.31 (0.63–2.74)
 1.15 (0.53–2.53)

≥ 15
 7
 36
 1.67 (0.66–4.27)
 1.67 (0.65–4.34)
 1.85 (0.71–4.84)
 1.90 (0.67–5.39)

P for trendf



0.13
 0.20
Proliferative without atypia






0
 46
 205
 2.04 (1.17–3.57)
 1.99 (1.13–3.50)
 1.00 (Ref)
 1.00 (Ref)

<5
 52
 235
 1.91 (1.11–3.29)
 1.82 (1.05–3.16)
 0.99 (0.63–1.55)
 0.99 (0.62–1.56)

5–15
 34
 123
 2.43 (1.34–4.41)
 2.40 (1.31–4.39)
 1.17 (0.70–1.94)
 1.14 (0.67–1.91)

≥ 15
 8
 60
 1.15 (0.48–2.75)
 1.09 (0.45–2.62)
 0.59 (0.26–1.33)
 0.61 (0.26–1.41)

P for trendf



0.49
 0.58
Proliferative with atypia






0
 23
 40
 5.57 (2.77–11.21)
 5.58 (2.74–11.38)
 1.00 (Ref)
 1.00 (Ref)

<5
 30
 45
 6.65 (3.43–12.90)
 6.48 (3.31–12.70)
 1.28 (0.62–2.67)
 1.29 (0.60–2.78)

5–15
 14
 25
 5.35 (2.39–12.01)
 5.26 (2.30–12.04)
 1.03 (0.42–2.51)
 1.02 (0.39–2.68)

≥ 15
 6
 16
 3.65 (1.27–10.47)
 3.46 (1.19–10.09)
 0.66 (0.22–1.97)
 0.59 (0.19–1.89)

P for trendf



0.21
 0.17

aNurses' Health Study I (1976 to 1994) and II (1989 to 1995). b Joint classification of BBD category and alcohol consumption where the reference group is women with nonproliferative BBD and 0 alcohol consumption. c The analysis is stratified by type of BBD where the reference group is women with 0 alcohol consumption within each category of BBD. dAdjusted for age at diagnosis, year of biopsy, and follow-up interval. eAdjusted for age at diagnosis, year of biopsy, and follow-up interval, age at menarche, body mass index quartiles, family history of breast cancer, parity/age at first birth, menopausal status/type of menopause, duration of postmenopausal hormone use. fTest for trend based on Wald test for continuous alcohol consumption. BBD, benign breast disease; CI, confidence interval; OR, odds ratio; Ref, reference group for statistical comparisons.

Tamimi et al. Breast Cancer Research 2005 7:R555   doi:10.1186/bcr1039