Table 2

Type II tumor suppressor genes expressed by myoepithelial cells

Myoepithelial tumor suppressor genes

Function

Reference

α-Smooth muscle actin

Cytoskeletal structure; suppress cell growth and motility

[97,98

Cytokeratin-5

Cytoskeletal structure; regulates cell growth

[99]

α₆ integrin

ECM receptor

[100]

Caveolin-1

Regulation of cell growth

[101]

Connexin-43

Gap junction protein

[102]

Maspin

Protease inhibitor

[68]

TIMP-1

Protease inhibitor

[17]

Relaxin

Hormone-regulation, cell growth

[103]

Activin

Hormone regulation

[58]

Adapted from Bissell and Radisky [65].

Adriance et al. Breast Cancer Research 2005 7:190   doi:10.1186/bcr1286