Figure 1.

Representative immunohistochemistry slides for Cks1, Skp2, and p27^Kip1 staining in breast cancer. Tumor cells of a grade II invasive duct cancer exhibiting strong and diffuse nuclear staining for Skp2 (S-phase kinase protein 2) and Cks1 (cyclin kinase subunit 1) (× 300) and low p27^Kip1 staining. Note the inversely low Skp2 and Cks1 staining with high p27^Kip1 staining of normal adjacent breast tissue (× 400).