Table 3 |
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|
MBD2 Haplotypes, menopausal status and breast cancer risk in Caucasians |
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|
MBD2 Haplotypes |
Frequency in cases |
Frequency in controls |
Crude OR (95% CI) |
ORa (95% CI) |
|
|
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|
All women |
||||
|
GC |
69.22% |
66.90% |
Reference |
Reference |
|
GG |
4.81% |
5.56% |
0.84 (0.53–1.31) |
0.82 (0.52–1.29) |
|
AC |
11.17% |
11.70% |
0.92 (0.68–1.26) |
0.92 (0.67–1.25) |
|
AG |
14.81% |
15.84% |
0.90 (0.69–1.19) |
0.90 (0.68–1.19) |
|
Premenopausal women |
||||
|
GC |
77.65% |
63.29% |
Reference |
Reference |
|
GG |
5.29% |
5.59% |
0.77 (0.33–1.80) |
0.77 (0.33–1.81) |
|
AC |
6.47% |
12.59% |
0.42 (0.21–0.85) |
0.40 (0.20–0.83) |
|
AG |
10.59% |
18.53% |
0.47 (0.26–0.83) |
0.47 (0.26–0.84) |
|
Postmenopausal women |
||||
|
GC |
66.83% |
68.75% |
Reference |
Reference |
|
GG |
4.67% |
5.54% |
0.87 (0.51–1.47) |
0.84 (0.49–1.44) |
|
AC |
12.50% |
11.25% |
1.14 (0.80–1.64) |
1.14 (0.79–1.65) |
|
AG |
16.00% |
14.46% |
1.14 (0.82–1.58) |
1.13 (0.81–1.57) |
|
|
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|
Values are expressed as n (%). aAdjusted for age (as a continuous variable), body mass index (<25 kg/m2, 25–29.99 kg/m2, >29.99 kg/m2), family history of breast cancer in first-degree relatives, menopausal status, family income (tertiles based on distribution of controls), lifetime months of breast feeding (never, 1–5, 6–15, ≥15 months) and study site. CI, confidence interval; OR, odds ratio. |
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|
Zhu et al. Breast Cancer Research 2005 7:R745 doi:10.1186/bcr1283 |
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