Table 3 |
|||
|
Correlation between PDGFR-α expression, PDGF-A expression and clinical–pathological parameters in invasive ductal carcinomas |
|||
|
Parameter |
PDGFR-α negative |
PDGFR-α positive |
P |
|
|
|||
|
PDGF-A |
|||
|
Negative |
19 (52.7%) |
2 (16.7%) |
|
|
Positive |
17 (47.3%) |
10 (83.3%) |
0.0290 |
|
Age (n) |
56.315 ± 11.913 (108) |
52.986 ± 12.811 (70) |
NS (0.0788) |
|
Tumour size, mm (n) |
31.406 ± 22.056 (106) |
30.101 ± 22.655 (69) |
NS (0.7057) |
|
Histological grade |
|||
|
I |
20 (19.4%) |
9 (12.8%) |
|
|
II |
38 (36.9%) |
34 (48.6%) |
|
|
III |
45 (43.7%) |
27 (38.6%) |
NS (0.2595) |
|
Axillary lymph node status |
|||
|
Negative |
47 (48%) |
18 (27.3%) |
|
|
Positive |
51 (52%) |
48 (72.7%) |
0.0079 |
|
Oestrogen receptor status |
|||
|
Negative |
30 (27.8%) |
19 (26.7%) |
|
|
Positive |
78 (72.2%) |
52 (73.3%) |
NS (0.8813) |
|
p53 |
|||
|
Negative |
38 (54.3%) |
21 (53.8%) |
|
|
Positive |
32 (45.7%) |
18 (46.2%) |
NS (0.9648) |
|
MIB-1 (n) |
19.449 ± 17.484 (49) |
12.333 ± 12.584 (15) |
NS (0.1491) |
|
HER-2 |
|||
|
Negative (0/1+) |
54 (57.4%) |
26 (40%) |
|
|
2+ |
17 (18.1%) |
10 (15.4%) |
|
|
3+ |
23 (24.5%) |
29 (44.6%) |
0.0265 |
|
Bcl2 |
|||
|
Negative |
29 (59.2%) |
15 (33.3%) |
|
|
Positive |
20 (40.8%) |
30 (66.7%) |
0.0121 |
|
Angiogenesis index (n) |
43.393 ± 26.498 (55) |
43.633 ± 27.635 (18) |
NS (0.9737) |
|
Patient survival, months (n) |
24.917 ± 19.500 (48) |
21.067 ± 20.405 (15) |
NS (0.5115) |
|
|
|||
|
NS, not statistically significant; PDGFR-α, platelet-derived growth factor receptor α; PDGF-A, platelet-derived growth factor A. |
|||
|
Carvalho et al. Breast Cancer Research 2005 7:R788 doi:10.1186/bcr1304 |
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