Table 3

Correlation between PDGFR-α expression, PDGF-A expression and clinical–pathological parameters in invasive ductal carcinomas

Parameter

PDGFR-α negative

PDGFR-α positive

P


PDGF-A

Negative

19 (52.7%)

2 (16.7%)

Positive

17 (47.3%)

10 (83.3%)

0.0290

Age (n)

56.315 ± 11.913 (108)

52.986 ± 12.811 (70)

NS (0.0788)

Tumour size, mm (n)

31.406 ± 22.056 (106)

30.101 ± 22.655 (69)

NS (0.7057)

Histological grade

I

20 (19.4%)

9 (12.8%)

II

38 (36.9%)

34 (48.6%)

III

45 (43.7%)

27 (38.6%)

NS (0.2595)

Axillary lymph node status

Negative

47 (48%)

18 (27.3%)

Positive

51 (52%)

48 (72.7%)

0.0079

Oestrogen receptor status

Negative

30 (27.8%)

19 (26.7%)

Positive

78 (72.2%)

52 (73.3%)

NS (0.8813)

p53

Negative

38 (54.3%)

21 (53.8%)

Positive

32 (45.7%)

18 (46.2%)

NS (0.9648)

MIB-1 (n)

19.449 ± 17.484 (49)

12.333 ± 12.584 (15)

NS (0.1491)

HER-2

Negative (0/1+)

54 (57.4%)

26 (40%)

2+

17 (18.1%)

10 (15.4%)

3+

23 (24.5%)

29 (44.6%)

0.0265

Bcl2

Negative

29 (59.2%)

15 (33.3%)

Positive

20 (40.8%)

30 (66.7%)

0.0121

Angiogenesis index (n)

43.393 ± 26.498 (55)

43.633 ± 27.635 (18)

NS (0.9737)

Patient survival, months (n)

24.917 ± 19.500 (48)

21.067 ± 20.405 (15)

NS (0.5115)


NS, not statistically significant; PDGFR-α, platelet-derived growth factor receptor α;

PDGF-A, platelet-derived growth factor A.

Carvalho et al. Breast Cancer Research 2005 7:R788-R795   doi:10.1186/bcr1304

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