|
Comparison of subjects carrying BRCA mutations |
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| Variable |
Control subjects (n = 1,073) |
Case subjects (n = 1,073) |
Pa |
|
|
|||
| Age (years) at interview, no. (%) |
|||
| ≤ 30 |
17 (1.6) |
26 (2.4) |
|
| 31–40 |
219 (20.4) |
242 (22.5) |
|
| 41–50 |
415 (38.7) |
386 (36.0) |
|
| 51–60 |
277 (25.8) |
264 (24.6) |
|
| ≥ 61 |
145 (13.5) |
155 (14.5) |
0.32 |
| Age (years) at interview, mean (SD) |
47.9 (10.6) |
48.6 (10.6) |
0.25 |
| Date of birth, mean year |
1951.8 |
1951.2 |
0.14 |
| Year of interview, mean (range) |
1999.7 (1995–2004) |
1999.8 (1999–2004) |
0.18 |
| Age (years) at diagnosis of breast cancer, no. (%) |
|||
| ≤ 30 |
NA |
107 (10.0) |
|
| 31–40 |
478 (44.5) |
||
| 41–50 |
371 (34.5) |
||
| ≥ 51 |
117 (10.9) |
||
| Age (years) at diagnosis of breast cancer, mean (SD) |
39.8 (8.3) |
||
| Mutation, % |
|||
| BRCA1 |
74.3 |
74.3 |
|
| BRCA2 |
25.7 |
25.7 |
|
| Parity |
|||
| No. (%) parous |
844 (79.6) |
879 (82.8) |
0.06 |
| Parity, mean (SD) |
1.9 (1.4) |
1.9 (1.3) |
0.18 |
| No. (%) who ever used oral contraceptives |
662 (62.6) |
710 (66.8) |
0.04 |
| No. (%) who ever smoked |
465 (43.3) |
471 (43.9) |
0.79 |
| Country of residence at time of testing, no. (%) |
|||
| Canada |
420 (39.1) |
420 (39.1) |
|
| Israel |
20 (1.9) |
20 (1.9) |
|
| UK |
8 (0.8) |
8 (0.8) |
|
| Poland |
189 (17.6) |
189 (17.6) |
|
| USA |
436 (40.6) |
436 (40.6) |
|
|
aAll P values are univariate and were derived using Student's t-test for continuous variables and the χ2 test for categorical variables. NA, not applicable; SD, standard deviation. | |||
Kotsopoulos et al. Breast Cancer Research 2005 7:R833 doi:10.1186/bcr1293 |
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