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Anthropometric variables in women with a deleterious BRCA1 or BRCA2 mutationa |
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| All |
Premenopausal |
Postmenopausal |
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| Variable |
Cases n = 1073 |
Controls n = 1073 |
P |
Cases n = 817 |
Controls n = 817 |
P |
Cases n = 256 |
Controls n = 256 |
P |
|
|
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| Weight (pounds) |
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| At birth |
7.1 (1.3) |
7.1 (1.3) |
0.67 |
NA |
NA |
NA |
NA |
NA |
NA |
| At age 18 |
120.6 (17.2) |
122.3 (19.1) |
0.03 |
121.5 (17.1) |
122.9 (19.2) |
0.11 |
117.8 (17.3) |
120.4 (18.5) |
0.10 |
| At age 30c |
130.9 (17.3) |
131.2 (18.5) |
0.75 |
131.9 (17.1) |
132.2 (18.5) |
0.87 |
127.9 (17.4) |
128.6 (18.6) |
0.69 |
| At age 40d |
137.7 (23.4) |
137.7 (24.3) |
0.99 |
139.7 (22.8) |
138.7 (25.0) |
0.63 |
135.3 (23.9) |
136.5 (23.4) |
0.59 |
| Current height (inches) |
64.2 (2.6) |
64.3 (2.6) |
0.44 |
64.3 (2.6) |
64.5 ± 2.6 |
0.50 |
63.9 ± 2.7 |
63.7 ± 2.7 |
0.10 |
| Body mass indexb |
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| At age 18 (kg/m2) |
20.57 (2.8) |
20.77 (3.0) |
0.10 |
20.65 (2.8) |
20.74 (3.0) |
0.52 |
20.31 (2.7) |
20.88 (2.9) |
0.03 |
| At age 30 (kg/m2)c |
22.35 (3.4) |
22.32 (3.7) |
0.88 |
22.44 (3.4) |
22.33 (3.9) |
0.56 |
22.08 (3.4) |
22.31 (3.1) |
0.43 |
| At age 40 (kg/m2)d |
23.77 (3.9) |
23.73 (3.9) |
0.88 |
24.06 (3.8) |
23.67 (4.1) |
0.26 |
23.42 (4.0) |
23.80 (3.7) |
0.29 |
| Weight gain (pounds) |
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| From age 18 to 30c |
10.5 (15.2) |
9.4 (17.0) |
0.14 |
10.6 (15.1) |
9.8 (18.2) |
0.35 |
10.1 (15.7) |
8.2 (13.0) |
0.23 |
| From age 30 to 40d |
9.4 (12.5) |
9.2 (13.3) |
0.82 |
10.6 (12.5) |
9.1 (15.3) |
0.23 |
7.9 (12.3) |
8.2 (10.5) |
0.23 |
| From age 18 to 40d |
18.6 (19.5) |
18.1 (20.4) |
0.71 |
19.9 (20.2) |
19.0 (22.1) |
0.61 |
17.0 (18.6) |
17.1 (18.2) |
0.98 |
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The subjects were women who did (case subjects) or did not (control subjects) have a diagnosis of invasive breast cancer. aP values are univariate and were derived using Student's t-test and include both BRCA1 and BRCA2 mutation carriers. Other values are means (standard deviations). bExcludes subjects with missing data on current height. cCalculated for pairs in which case subjects were diagnosed at age >30 years. dCalculated for pairs in which case subjects were diagnosed at age >40 years. NA, not applicable. | |||||||||
Kotsopoulos et al. Breast Cancer Research 2005 7:R833 doi:10.1186/bcr1293 |
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