|
Weight change and subsequent cancer risk: subjects stratified by their age at diagnosis of cancer |
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| Weight change between age 18 and 30 years |
Cases (number) |
Controls (number) |
ORa (95% CI) |
P |
P for trend |
|
|
|||||
| In all subjectsb |
966 |
966 |
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| Loss of at least 10 pounds |
53 |
81 |
0.66 (0.46–0.93) |
0.03 |
|
| Loss of <10 to gain of ≤ 10 pounds |
536 |
542 |
1 (referent) |
||
| Gain of 10 to ≤ 20 pounds |
227 |
190 |
1.19 (0.96–1.49) |
0.12 |
|
| Gain of > 20 pounds |
150 |
135 |
1.00 (0.77–1.30) |
0.99 |
0.46 |
| According to case subjects' age at diagnosis |
|||||
| >30 to ≤ 40 yearsc |
478 |
478 |
|||
| Loss of at least 10 pounds |
23 |
49 |
0.47 (0.28–0.79) |
0.005 |
|
| Loss of <10 to gain of ≤ 10 poundsd |
255 |
254 |
1 (referent) |
||
| Gain of 10 to ≤ 20 pounds |
112 |
89 |
1.25 (0.91–1.71) |
0.17 |
|
| Gain of >20 pounds |
88 |
86 |
1.03 (0.72–1.47) |
0.88 |
0.48 |
| >40 yearsd |
488 |
488 |
|||
| Loss of at least 10 pounds |
30 |
32 |
0.97 (0.52–1.65) |
0.91 |
|
| Loss of <10 to gain of ≤ 10 poundsd |
281 |
288 |
1 (referent) |
||
| Gain of 10 to ≤ 20 pounds |
115 |
101 |
1.16 (0.85–1.59) |
0.36 |
|
| Gain of >20 pounds |
62 |
67 |
0.95 (0.64–1.43) |
0.82 |
0.75 |
|
Subjects were women with a deleterious mutation in BRCA1 or BRCA2 who did (case subjects) or did not (control subjects) receive a diagnosis of cancer. aAll odds ratios (ORs) were derived using univariate conditional logistic regression. bExcludes case subjects diagnosed at age ≤ 30 years. cExcludes case subjects diagnosed at age ≤ 30 and >40 years. dExcludes case subjects diagnosed at ≤ 40 years. CI, confidence interval. | |||||
Kotsopoulos et al. Breast Cancer Research 2005 7:R833 doi:10.1186/bcr1293 |
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