Table 4

Weight change and subsequent cancer risk: subjects stratified by their BRCA mutation
Weight change between age 18 and 30 years
 Cases (n)
 Controls (n)
 ORa (95% CI)
 P
 P for trend
In BRCA1 mutation carriers
 370
 370


     Loss of at least 10 pounds
 13
 38
 0.35 (0.18–0.67)
 0.002
     Loss of <10 to gain of ≤ 10 poundsd
 188
 189
 1 (referent)

     Gain of 10 to ≤ 20 pounds
 93
 72
 1.29 (0.91–1.83)
 0.15
     Gain of >20 pounds
 76
 71
 1.09 (0.73–1.62)
 0.67
 0.34
In BRCA2 mutation carriers
 108
 108


     Loss of at least 10 pounds
 10
 11
 0.88 (0.35–2.23)
 0.78
     Loss of <10 to gain of ≤ 10 poundsd
 67
 65
 1 (referent)

     Gain of 10 to ≤ 20 pounds
 19
 17
 1.08 (0.50–2.35)
 0.84
          Gain of >20 pounds
 12
 15
 0.77 (0.33–1.81)
 0.55
 0.70

Subjects were women with a deleterious mutation in BRCA1 or BRCA2 who did (case subjects) or did not (matched control subjects) receive a diagnosis of breast cancer at age 30 to 39 years. aAll odds ratios (ORs) were derived using univariate conditional logistic regression. CI, confidence interval.

Kotsopoulos et al. Breast Cancer Research 2005 7:R833   doi:10.1186/bcr1293

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