Table 5

Weight change and subsequent cancer risk: subjectsa stratified by BRCA mutation and parity
Weight change between age 18 and 30 years
 Cases (number)
 Controls (number)
 ORc (95% CI)
 P
 P for trendd
In BRCA1 mutation carriers




     Loss of <10 to gain of ≤ 10 poundsb
 188
 189
 1 (referent)

     Gain of >10 pounds




          Parity = 0
 24
 28
 0.88 (0.50–1.55)
 0.66
          Parity = 1
 26
 27
 0.94 (0.52–1.72)
 0.85
          Parity ≥ 2
 117
 84
 1.44 (1.01–2.04)
 0.04
 0.16
          Parity unknown
 2
 4


In BRCA2 mutation carriers




     Loss of <10 to gain of ≤ 10 poundsb
 67
 65
 1 (referent)

     Gain of >10 pounds




          Parity = 0
 6
 4
 1.44 (0.40–5.13)
 0.58
          Parity = 1
 7
 6
 1.10 (0.33–3.72)
 0.87
          Parity ≥ 2
 18
 22
 0.73 (0.33–1.64)
 0.45
 0.31
          Parity unknown
 0
 0


aWhose cancer was diagnosed when they were 30 to 39 years old. bA negative number indicates weight loss. cAll ORs were derived using univariate conditional logistic regression. dExcludes subjects in the weight-gain ≤ -10 group.

Kotsopoulos et al. Breast Cancer Research 2005 7:R833   doi:10.1186/bcr1293