What does an orphan G-protein-coupled receptor have to do with estrogen?
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* Corresponding author: James M Rae jimmyrae@umich.edu
1 Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA
2 Department of Oncology, Georgetown University, Washington, District of Columbia, USA
Breast Cancer Research 2005, 7:243-244 doi:10.1186/bcr1330
Published: 29 September 2005Abstract
Estrogen affects multiple aspects of human physiology, including the normal growth and development of female reproductive tissues, bone integrity, cardiovascular and central nervous system functions, and plays a central role in normal mammary development and breast pathogenesis. It modulates diverse cell signaling pathways, some of which appear to be independent of the known estrogen receptors (ERs). Although many of estrogen's actions can be explained by the nuclear ERs (ER-α and ER-β) functioning as ligand-activated RNA transcription factors, there are numerous rapid biochemical and physiological responses that cannot be explained by the classical genomic effects of estrogen signaling. It has long been postulated that the rapid effects of estrogen are due to a membrane-bound ER, and two recent reports suggest that it is in fact a G-protein-coupled receptor named 'GPR30'.