Table 1

Summary of histological, immunohistochemical and chromogenic in situ hybridization findings
Case
 Histological type
 HER2 (Herceptest®)
 HER2 (CB11)
 EGFR (IHC)
 EGFR (CISH)
1
 Carcinoma with squamous metaplasia
 -
 -
 3+
 No amp
2
 Carcinoma with squamous metaplasia
 -
 -
 3+
 No amp
3
 Carcinoma with squamous metaplasia
 -
 -
 3+
 No amp
4
 Carcinoma with squamous metaplasia
 -
 -
 3+
 No amp
5
 Carcinoma with squamous metaplasia
 -
 -
 3+
 Amp
6
 Carcinoma with squamous metaplasia
 -
 -
 3+
 Amp
7
 Carcinoma with squamous metaplasia
 1+
 -
 3+
 No amp
8
 Carcinoma with squamous metaplasia
 -
 -
 3+
 Amp
9
 Carcinoma with squamous metaplasia
 -
 -
 1+
 No amp
10
 Spindle cell carcinoma
 -
 -
 3+
 No amp
11
 Spindle cell carcinoma
 -
 -
 3+
 No amp
12
 Spindle cell carcinoma
 -
 -
 1+
 No amp
13
 Spindle cell carcinoma
 -
 -
 3+
 Amp
14
 Spindle cell carcinoma
 -
 -
 -
 No amp
15
 Spindle cell carcinoma
 -
 -
 3+
 Amp
16
 Spindle cell carcinoma
 -
 -
 -
 No amp
17
 Spindle cell carcinoma
 -
 -
 3+
 Amp
18
 Spindle cell carcinoma
 -
 -
 3+
 No amp
19
 Spindle cell carcinoma
 2+a
 1+a
 3+
 Amp
20
 Carcinoma with heterologous elements
 -
 -
 3+
 No amp
21
 Carcinoma with heterologous elements
 -
 -
 3+
 No amp
22
 Matrix producing carcinoma
 -
 -
 1+
 No amp
23
 Matrix producing carcinoma
 -
 -
 -
 No amp
24
 Matrix producing carcinoma
 -
 -
 3+
 No amp
25
 Matrix producing carcinoma
 -
 -
 3+
 No amp

aNo HER2 gene amplification was detected by CISH. Amp, amplification; CISH, chromogenic in situ hybridization; EGFR, epidermal growth factor receptor; HER, epidermal growth factor receptor; IHC, immunohistochemistry.

Reis-Filho et al. Breast Cancer Research 2005 7:R1028   doi:10.1186/bcr1341

Open Data