Breast Cancer Research

official impact factor 5.79

Open Access Research article

The progestational and androgenic properties of medroxyprogesterone acetate: gene regulatory overlap with dihydrotestosterone in breast cancer cells

Radhika P Ghatge*, Britta M Jacobsen, Stephanie A Schittone and Kathryn B Horwitz

Author Affiliations

University of Colorado Health Sciences Center, Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, Denver, Colorado, USA

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Breast Cancer Research 2005, 7:R1036-R1050 doi:10.1186/bcr1340

Published: 2 November 2005

Additional files

Additional File 1:

Excel files containing tables showing the genes regulated by progesterone and MPA in T47D breast cancer cells: A, MPA upregulated; B, progesterone upregulated; C, MPA downregulated; D, progesterone downregulated; E, upregulated by both progesterone and MPA; F, downregulated by both progesterone and MPA.

Format: ZIP Size: 123KB Download file

Open Data

Additional File 2:

Excel files containing tables showing the genes regulated by DHT and MPA in Y-AR breast cancer cells: A, DHT upregulated; B, MPA 1 μmol/l upregulated; C, MPA 10 nmol/l upregulated; D, DHT downregulated; E, 1 MPA μmol/l downregulated; F, MPA 10 nmol/l downregulated; G, upregulated through AR and PR.

Format: ZIP Size: 53KB Download file

Open Data