Table 2 |
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|
Top 33 dual regulated genes |
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|
GenBank ID |
AR |
PR |
Description |
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|
|
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|
MPA |
DHT |
MPA |
P |
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|
|
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|
67.53 |
51.80 |
23.33 |
29.48 |
Serum/glucocorticoid regulated kinase |
|
|
31.45 |
33.87 |
6.39 |
11.72 |
Sodium channel, nonvoltage-gated 1, gamma |
|
|
26.17 |
11.44 |
37.57 |
31.08 |
ti27d10.x1 NCI_CGAP_Kid11 Homo sapiens cDNA clone IMAGE:2131699 3', mRNA sequence. |
|
|
11.91 |
11.13 |
4.23 |
4.04 |
Pyruvate dehydrogenase kinase, isoenzyme 4 |
|
|
11.10 |
9.08 |
3.15 |
3.21 |
FK506 binding protein 5 |
|
|
10.88 |
11.23 |
4.77 |
3.14 |
TCDD-inducible poly(ADP-ribose) polymerase |
|
|
8.33 |
7.36 |
6.22 |
5.29 |
Prickle-like 1 (Drosophila) |
|
|
7.54 |
5.38 |
4.74 |
4.69 |
Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) |
|
|
6.82 |
11.65 |
15.98 |
15.80 |
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) |
|
|
6.76 |
6.39 |
20.32 |
12.77 |
Coagulation factor III (thromboplastin, tissue factor) |
|
|
6.01 |
5.99 |
4.61 |
2.84 |
Coagulation factor II (thrombin) receptor |
|
|
5.82 |
8.07 |
12.62 |
12.49 |
Interleukin 20 receptor, alpha |
|
|
5.06 |
4.63 |
8.18 |
8.43 |
Hypothetical protein FLJ11127 |
|
|
4.63 |
4.34 |
10.19 |
10.50 |
N-myc downstream regulated gene 1 |
|
|
4.42 |
4.95 |
4.06 |
3.76 |
SEC14-like 2 (S. cerevisiae) |
|
|
4.22 |
3.96 |
2.58 |
2.68 |
FK506 binding protein 5 |
|
|
4.07 |
3.95 |
2.91 |
3.38 |
Lymphoid enhancer-binding factor 1 |
|
|
4.00 |
8.54 |
16.37 |
13.28 |
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) |
|
|
3.71 |
3.53 |
2.16 |
2.27 |
Protein kinase, AMP-activated, beta 2 non-catalytic subunit |
|
|
3.61 |
4.13 |
3.87 |
3.14 |
SPRY domain-containing SOCS box protein SSB-1 |
|
|
3.47 |
3.00 |
5.59 |
3.30 |
Homo sapiens transcribed sequence with moderate similarity to protein ref:NP_060265.1 (H.sapiens) |
|
|
3.32 |
3.23 |
2.46 |
2.22 |
FK506 binding protein 5 |
|
|
3.31 |
3.18 |
3.73 |
3.45 |
Homo sapiens cDNA FLJ42287 fis, clone TLIVE2005866 |
|
|
3.27 |
2.81 |
3.17 |
2.56 |
Homo sapiens LOC374963 (LOC374963), mRNA |
|
|
3.17 |
4.55 |
8.33 |
8.02 |
Match: proteins: Tr:Q9UJ12 Tr:O43723 Tr:Q9VZN3 |
|
|
3.06 |
4.89 |
4.69 |
4.83 |
Kruppel-like factor 4 (gut) |
|
|
3.06 |
4.81 |
2.52 |
2.36 |
603295907F1 NIH_MGC_96 Homo sapiens cDNA |
|
|
2.82 |
2.24 |
2.12 |
2.14 |
AL562398 Homo sapiens NEUROBLASTOMA COT 25-NORMALIZED |
|
|
2.78 |
2.88 |
2.79 |
2.03 |
Solute carrier family 6 (neurotransmitter transporter, taurine), member 6 |
|
|
2.77 |
2.43 |
2.33 |
2.18 |
Chromosome 9 open reading frame 52 |
|
|
2.73 |
4.33 |
8.09 |
7.66 |
Kruppel-like factor 4 (gut) |
|
|
|
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|
Shown are the top genes and their fold upregulation in Y-AR (AR+) and T47D (PR+) cells treated with physiologic concentrations of MPA and either DHT or progesterone. AR, androgen receptors; DHT, dihydrotestosterone; MPA, medroxyprogesterone acetate; P, progesterone; PR, progesterone receptor. |
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|
Ghatge et al. Breast Cancer Research 2005 7:R1036 doi:10.1186/bcr1340 |
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