Figure 1.

Hypothetical model of tumor subtypes classified by chromosomal 18q and 8p allelic imbalance (AI) status. Inactivation of tumor suppressor genes (TSGs) on either 8p or 18q lead to the formation of two subtypes of invasive ductal carcinoma (IDC) with different risks of distant relapse. Some of the AIs are associated with the inactivation of TSGs, whereas others are non-specific events (denoted by asterisks).