Table 2

Upregulated genes in MCF-7 cells after exposure to rapamycin plus CN-A for 12 hours

Gene expression ratio

GenBank number

Gene name

Rapamycin + CN-A

Rapamycin

CN-A

NM_000358.1

Transforming growth factor-β-induced 68 kDa (TGFBI)

8.16

1.74

5.2

NM_001038.1

Sodium channel, nonvoltage-gated 1α(SCNN1A)

6.99

1.49

4.26

NM_002281.2

Keratin, hair, basic-1 (KRTHB1)

6.96

1.27

12.8^a

NM_001197.3

BCL2-interacting killer (apoptosis-inducing; BIK)

6.76

2.37

3.59

NM_004354.1

Cyclin G₂ (CCNG2)

6.08

3.07

3.22

NM_005310.1

Growth factor receptor-bound protein 7 (GRB7)

5.81

2.48

2.61

NM_020898.1

KIAA1536 protein (KIAA1536)

5.42

2.78

1.8

NM_030777.2

Solute carrier family 2, member 10 (SLC2A10)

5.09

1.53

2.51

NM_005727.2

Tetraspan 1 (TSPAN-1)

4.61

1.54

1.76

NM_024709.1

Hypothetical protein FLJ14146 (FLJ14146)

4.55

1.8

2.53

NM_014376.1

Cytoplasmic FMR1 interacting protein 2 (CYFIP2)

4.21

2.43

1.66

NM_017644.1

Hypothetical protein FLJ20059 (FLJ20059)

4.09

1.51

1.2

NM_002166.1

Inhibitor of DNA binding 2 (ID2)

4.03

1.23

2.93

NM_006813.1

Proline rich 2 (PROL2)

3.87

2.8

1.9

NM_002885.1

RAP1, GTPase activating protein 1 (RAP1GA1)

3.81

1.56

2.51

NM_000755.2

Carnitine acetyltransferase (CRAT)

3.79

1.75

2.45

NM_031477.2

Hypothetical protein MGC10500 (MGC10500)

3.72

2.18

2.29

NM_012257.2

HMG-box containing protein 1 (HBP1)

3.7

1.67

1.55

NM_020169.2

Latexin protein (LXN)

3.68

2.49

2.40

NM_014417.2

BCL2 binding component 3 (BBC3)

3.55

1.82

2.18

NM_024642.2

GalNAc-T12 (GALNT12)

3.49

1.49

2.53

NM_016162.1

Inhibitor of growth family, member 4 (ING4)

3.47

1.98

1.73

NM_017673.2

Chromosome 1 open reading frame 26 (C1orf26)

3.45

1.44

2.93

NM_014353.2

RAB26, member RAS oncogene family (RAB26)

3.42

2.40

1.49

NM_005178.2

B-cell CLL/lymphoma 3 (BCL3)

3.39

1.05

3.31

^aIncreased upper reliable levels. CN-A, cotylenin A.

Kasukabe et al. Breast Cancer Research 2005 7:R1097   doi:10.1186/bcr1344