Table 4

Effects of rapamycin plus CN-A on cell cycle regulatory genes

Gene expression ratio

Gene name

Rapamycin + CN-A

Rapamycin

CN-A

Cyclin A₂

0.51

0.54

0.82

Cyclin B₁

0.71

0.77

0.84

Cyclin B₂

0.84

0.89

0.89

Cyclin D₁

0.94

0.96

1

Cyclin D₃

0.86

0.7

1.09

Cyclin E₁

0.44

0.67

0.66

Cyclin E₂

0.53

0.64

0.87

Cyclin G₁

1.43

1.25

1.02

Cyclin G₂

6.08

3.07

3.22

Cyclin-dependent kinase 2 (CDK2)

0.58

0.78

0.83

Cyclin-dependent kinase 4 (CDK4)

0.62

0.81

0.77

Cell division cycle 2 (CDC2)

0.62

0.7

0.85

P53

1.37

1.52

1.32

P21 (Cip1)

0.85

0.83

1.03

P27 (Kip1)

1.65

1.39

1.18

Retinoblastoma 1 (RB1)

1.08

1.09

1.04

Retinoblastoma-like 1 (p107)

0.53

0.67

0.87

Retinoblastoma-like 2 (p130)

1.96

2.18

1.07

E2F transcription factor 3 (E2F3)

0.42

0.86

E2F transcription factor 5, p130-binding (E2F5)

0.96

1.21

0.81

E2F transcription factor 6 (E2F6)

0.62

0.70

0.65

CN-A, cotylenin A.

Kasukabe et al. Breast Cancer Research 2005 7:R1097   doi:10.1186/bcr1344