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Open Access Highly Access Research article

Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts

Yudi Pawitan1, Judith Bjöhle2, Lukas Amler3, Anna-Lena Borg2, Suzanne Egyhazi2, Per Hall1, Xia Han4, Lars Holmberg5, Fei Huang4, Sigrid Klaar2, Edison T Liu6, Lance Miller6, Hans Nordgren7, Alexander Ploner1, Kerstin Sandelin8, Peter M Shaw4, Johanna Smeds2, Lambert Skoog2, Sara Wedrén1 and Jonas Bergh2*

Author Affiliations

1 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

2 Department of Oncology and Pathology, Radiumhemmet, Karolinska Institutet and University Hospital, Stockholm, Sweden

3 Genentech, San Francisco, California, USA

4 Bristol-Myers Squibb, Princeton, New Jersey, USA

5 Regional Oncological Center, Uppsala University Hospital, Uppsala, Sweden

6 Genome Institute of Singapore, Singapore

7 Department of Pathology, Uppsala University Hospital, Uppsala, Sweden

8 Department of Surgery Sciences, Karolinska Institutet and Hospital, Stockholm, Sweden

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Breast Cancer Research 2005, 7:R953-R964 doi:10.1186/bcr1325

Published: 3 October 2005

Additional files

Additional file 1:

Supplementary Report presenting (i) details of gene filtering, (ii) details of cross-validation procedure to choose 64-gene signature, (iii) list of 64 genes, and (iv) other statistical analyses based on secondary endpoints.

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