Table 5

Main biological functions among the present 64-gene set and the 70-gene set from the van't Veer study

Biological function

64-gene set (present study)

70-gene set (van't Veer and colleagues)

DNA replication/transcription/nucleosome assembly

IGF1, RRM2×2, TOP2A

ORC6L, MCM6, RFC4

PFS2, CENPF, HOXA5, CBFA2T1, SETBP1, UHRF1, MKI67, HIST1H2BG, H2AFZ

KIAA1442, CENPA

Cell cycle/proliferation/growth

CDKN1C, PTN, CDC2×2,

EXT1, HEC, PRC1, NUSAP1 (LOC51203), MCM6, Cyclin E2, TGFB3, FLT1, FGF18, ECT2, GMPS, IGFBP5 × 2, ESM1, WISP1

BUB1B, ESPL1, PRC1, TOP2A, NUSAP1 (LOC51203), CENPF, IGF1, RHOJ, UHRF1,PDGFD, CBFA2T1, NOV

Apoptosis

ESPL1

FLT1

Cell adhesion/motility/invasion/metastasis

SLIT2, COL14A1, FLRT2, MFAP4, CLDN7, IGF1, RHOJ

WISP1, FGF18, MMP9

Angiogenesis

PTN

FLT1

Signal transduction

IGF1, RHOJ,

EXT1, GNAZ, GFBP5, CFFM4, FGF18, NMU, RAB6B, PK428, PK428 MP1, WISP1, DKFZP564D0462 (GPR126)

PTN, DNM1, GPR56

Pawitan et al. Breast Cancer Research 2005 7:R953   doi:10.1186/bcr1325