Table 2 |
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Correspondence of combination index values to combined drug effects in the MCF-7 cell line |
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|
Drug associationa |
Iban + TAM |
Iban + ICI |
|
|
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|
50% CI, mean (SD) |
1.0 (0.1) |
0.9 (0.2) |
|
Combination effect |
Additive |
Additive |
|
75% CI, mean (SD) |
1.1 (0.1) |
1.0 (0.3) |
|
Combination effect |
Additive |
Additive |
|
|
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|
The 50% and 75% combination index values corresponding to drug concentrations leading to 50% and 75% cell growth, respectively, were determined by crystal violet staining assay, as detailed in Materials and methods. aExposure to ibandronate (Iban) and/or 4-hydroxytamoxifen (TAM) or ICI 182,780 (ICI) for 72 hours in three separate experiments. SD, standard deviation. |
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Journe et al. Breast Cancer Research 2006 8:R2 doi:10.1186/bcr1363 |
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