Table 2

Components of the epidermal growth factor receptor pathway affected by copy number change

Gene

Locus

MCF-7

BT-474

ZR-75-30

UACC-893

Sk-Br-3

MDA-MB-231

T47D

EGF

4q25

+

TGFA

2p13.3

-

-

NRG2

5q31.2

+

NRG1

8p12

--

--

-

EGFR

7p12.3-p12.1

+

+

ErBB2

17q12

+++

+++

+++

+++

ErBB3

12q13

ErBB4

2q33.3-q34

SH3KBP1

Xp22.12

--

RASA2

3q23

+

+

VAV2

9q34.2

+

+

-

GRB2

17q25.1

++

+++

PLCG1

20q12

+++

-

+

+

PLCG2

16q23.2

-

-

+

RNTRE

10p14

+

SSH3BP1

10p12.1

+

SOS1

2p22.1

-

-

PTK2B

8p21.2

-

-

--

--

SRC

20q11.23

--

+++

++

NRAS

1p13.2

+++

-

CDC42

1p36.12

-

RAC1

7p22.1

+

RIN1

11q13.2

+

RAF1

3p25.2

+

+

MAP3K4

6q26

--

-

MAP3K11

11q13.1

+

+++

PAK1

11q13.5

+

ADAM9

8p11.23

+

ADAM12

10q26.2

---

-

ADAM17

2p25.1

+

RAB5a

3p24.3

+

MAP2K1

15q21

-

MAP2K7

19p13.2

-

MAP2K4

17q11.2

--

--

MAP2K3

17p11.2

-

-

-

MAP2K6

17q24.3

+++

+

+

PDPK1

16p13.3

+

CHN2

7p15.1

+

+

++

+

PRKCA

17q24.2

+++

++

+

+

ERK1

16p11.2

+

ERK2

22q11.21

-

MAPK8

10q11.22

+

MAPK9

5q35.3

-

-

MAPK14

6p21.31

++

AKT1

14q32.33

+

+

+

BAD

11q13.1

+++

LIMK1

7q11.23

+

+++

+++

+

PLD1

3q26.31

+

++

RPS6KA3

Xp22.12

-

FOS

14q24.3

+

JUN

1p32-p31

-

TP53

17p13.1

+

--

-

MYC

8q24

+++

++

+++

+

+++

+

ELK1

Xp11.23

-

-

+

JUN

1p32.1

-

EGF

4q25

+

Scores: +, log₂ ratio +0.4 to +0.7; ++, log₂ ratio +0.7 to +0.99; +++, log₂ ratio more than +1.0; -, log₂ ratio -0.4 to -0.7; --, log₂ ratio -0.7 to -0.99; ---, log₂ ratio less than -1.0.

Shadeo and Lam Breast Cancer Research 2006 8:R9   doi:10.1186/bcr1370