Array-CGH and breast cancer

doi:10.1186/bcr1510

Breast Cancer Research

Volume 8
Issue 3

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Review

Array-CGH and breast cancer

Erik H van Beers¹ and Petra M Nederlof²

¹Division of Experimental Therapy, Netherlands Cancer Institute NKI-AVL, Amsterdam

²Department of Pathology, Netherlands Cancer Institute NKI-AVL, Amsterdam, The Netherlands

author email corresponding author email

Breast Cancer Research 2006, 8:210doi:10.1186/bcr1510


Published:	30 June 2006

Abstract

The introduction of comparative genomic hybridization (CGH) in 1992 opened new avenues in genomic investigation; in particular, it advanced analysis of solid tumours, including breast cancer, because it obviated the need to culture cells before their chromosomes could be analyzed. The current generation of CGH analysis uses ordered arrays of genomic DNA sequences and is therefore referred to as array-CGH or matrix-CGH. It was introduced in 1998, and further increased the potential of CGH to provide insight into the fundamental processes of chromosomal instability and cancer. This review provides a critical evaluation of the data published on array-CGH and breast cancer, and discusses some of its expected future value and developments.