Table 1

Studies using array-CGH on breast cancer samples or breast cancer cell lines

Patient source or cell line

Array platform

Resolution (Mb)

Ref.

2 Human cell lines, inclusing breast (BT474)

18,664 oligo nucleotides

~0.15

[16]

BC (n = 5)

32 k tiling BAC

Sub-Mb

[17]

Primary BC (n = 33), BC cell line (n = 27)

Genome-wide BAC and high resolution on 8p11-12

~1.5

[18]

FFPE BC (n = 44)

4153 BAC

<1

[24]

Comparison of FFPE with frozen BC

2464 BAC

1.5

[27]

Gain in 47% BC (unpublished results)

See Pinkel and coworkers [2]

[32]

FFPE BC (n = 31)

471 BAC/PAC

15

[47]

BRCA1 (n = 14), BRCA2 (n = 12), sporadic (n = 26)

3.5 k BAC

1

[58]

1 Case report

1777 BAC

~1.5

[66]

24 pairs LCIS + ILC

~2400 BAC

1.5

[68]

4 synchronous tumours (2 BC and 2 leiomyosarcomas)

2.5 k BAC

1.5

[70]

BC cell line (n = 1)

6 k BAC

<1

[93]

11 BC cell lines

2464 BAC (Hum-Array1.14)

1.5

[95]

52 node-negative invasive BC

57 oncogene loci (AmpliOnc™)

[96]

Premenopausal BC and radiation (n = 47)

3.5 k BAC

1

[107]

16 cell lines (8 of them BC)

9862 SNPs

[108]

2 BC cell lines

2560 BAC

1.5

[109]

47 fresh-frozen IDC BC

4134 BAC

0.9

[110]

BAC, bacterial artificial chromosome; BC, breast cancer; CGH, comparative genomic hybridization; FFPE, formalin-fixed paraffin-embedded; IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; LCIS, lobular carcinoma in situ; SNP, single nucleotide polymorphism.

van Beers and Nederlof Breast Cancer Research 2006 8:210   doi:10.1186/bcr1510