Table 4

Relative risks of breast cancer death associated with tumor size, grade, and recurrence score among ER-positive patients, stratified by treatment with tamoxifen
Score
 Cases
 Controls
 RR
 95% CI
 P value
Tamoxifen treated (55 cases and 150 controls)
Multivariate analyses without Recurrence Score1






     Tumor size (cm)





0.009
          Continuous2
 55
 (100%)
 150
 (100%)
 2.6
 (1.2–5.5)
     Grade (pathologist 1)





0.007
          Well
 6
 (11%)
 50
 (33%)
 1.0
 reference
          Moderate
 28
 (51%)
 69
 (46%)
 2.8
 (1.1–7.4)
          Poor
 21
 (38%)
 31
 (21%)
 4.5
 (1.6–12.3)
Multivariate analyses with Recurrence Score3
     Tumor size (cm)





0.013
          Continuous2
 55
 (100%)
 150
 (100%)
 2.5
 (1.2–5.4)
     Grade (pathologist 1)





0.126
          Well
 6
 (11%)
 50
 (33%)
 1.0
 reference
          Moderate
 28
 (51%)
 69
 (46%)
 2.4
 (0.9–6.4)
          Poor
 21
 (38%)
 31
 (21%)
 2.8
 (0.9–9.3)
     Recurrence Score





0.003
          Continuous4
 55
 (100%)
 150
 (100%)
 5.3
 (1.6–17.2)
Tamoxifen untreated (110 cases and 251 controls)
Multivariate analyses without Recurrence Score1
     Tumor size (cm)





0.035
          Continuous2
 110
 (100%)
 251
 (100%)
 1.8
 (1.0–3.1)
     Grade (pathologist 1)





<0.001
          Well
 17
 (15%)
 83
 (33%)
 1.0
 reference
          Moderate
 54
 (49%)
 131
 (52%)
 2.0
 (1.1–3.6)
          Poor
 39
 (35%)
 37
 (15%)
 4.7
 (2.3–9.9)
Multivariate analyses with Recurrence Score3
     Tumor size (cm)





0.036
          Continuous2
 110
 (100%)
 251
 (100%)
 1.8
 (1.0–3.1)
     Grade (pathologist 1)





0.018
          Well
 17
 (15%)
 83
 (33%)
 1.0
 reference
          Moderate
 54
 (49%)
 131
 (52%)
 1.8
 (1.0–3.4)
          Poor
 39
 (35%)
 37
 (15%)
 3.2
 (1.4–7.2)
     Recurrence Score





0.025
          Continuous4
 110
 (100%)
 251
 (100%)
 2.4
 (1.1–5.2)

1Conditional logistic regression models include tumor size and tumor grade only. 2Relative risks for tumor size calculated with regard to an increment of 2 cm. 3Conditional logistic regression models include tumor size, tumor grade, and Recurrence Score. 4Relative risks for Recurrence Score calculated with regard to an increment of 50 units (chosen to be consistent with and comparable to previous studies). CI, confidence interval; ER, estrogen receptor; RR, relative risk.

Habel et al. Breast Cancer Research 2006 8:R25   doi:10.1186/bcr1412

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