Table 1 |
|||
|
Association between BRCA1 methylation and AI at the BRCA loci and other tumor features |
|||
| Primary sporadic breast tumours |
BRCA1 promoter methylation |
P value |
|
|
|
|||
| Yes (n = 13) |
No (n = 130) |
||
|
|
|||
| AI at the BRCA1 locus |
|||
| Yes |
8 (62%) |
41 (35%) |
|
| No |
5 (38%) |
77 (65%) |
0.0731 |
| ND/NA |
12 |
||
| AI at the BRCA2 locus |
|||
| Yes |
5 (38%) |
37 (30%) |
|
| No |
8 (62%) |
85 (70%) |
0.5420 |
| ND/NA |
8 |
||
| TP53 mutations |
|||
| Mutated TP53 gene |
5 (38%) |
22 (17%) |
|
| Wild type |
8 (62%) |
106 (83%) |
0.1299 |
| ND/NA |
2 |
||
| Estrogen receptor |
|||
| Negative |
7 (54%) |
33 (25%) |
|
| Positive |
6 (46%) |
97 (75%) |
0.0475 |
| ND/NA |
|||
| Progesterone receptor |
|||
| Negative |
6 (50%) |
57 (44%) |
|
| Positive |
6 (50%) |
72 (56%) |
0.7699 |
| ND/NA |
1 |
1 |
|
| Age at diagnosis |
|||
| ≤ 55 years |
9 (69%) |
57(44%) |
|
| >55 years |
4 (31%) |
73 (56%) |
0.0898 |
|
|
|||
|
AI, allelic imbalance; ND/NA, not determined/not available. |
|||
|
Birgisdottir et al. Breast Cancer Research 2006 8:R38 doi:10.1186/bcr1522 |
|||
