Table 2

Phenotypic features of the BRCA1 methylated tumors
Tumour number
 AI at BRCA1
 AI at BRCA2
 TP53 mutation
 ER status
 PR status
 BRCA1 protein expressiona
 DNA index
 Interpretation of FISH
1
 +
 -
 -
 +
 +
 1
 NA
 Deletion of the BRCA1 region
2
 +
 -
 -
 -
 -
 1
 1.68
 Deletion of the BRCA1 region
3
 +
 +
 +
 -
 -
 1
 1.12; 1.99
 Chromosome 17 deletion
4
 +
 +
 +
 -
 -
 1
 1.54
 Chromosome 17 deletion
5
 +
 +
 +
 +
 +
 1
 1.22; 2.18
 Chromosome 17 deletion
6
 -
 -
 -
 +
 +
 1
 NA
 Chromosome 17 deletion
7
 +
 -
 +
 -
 -
 1
 3.32
 No detectable BRCA1 deletion
8
 -
 -
 -
 +
 +
 1
 1.11; 1.80
 No detectable BRCA1 deletion
9
 +
 +
 +
 -
 -
 1
 1.00
 No detectable BRCA1 deletion
10
 -
 -
 -
 +
 +
 2
 1.69
 No detectable BRCA1 deletion
11
 -
 -
 -
 -
 -
 3
 1.00
 No detectable BRCA1 deletion
12
 -
 -
 -
 +
 +
 3
 2.09
 No detectable BRCA1 deletion
13
 +
 +
 -
 -
 NA
 3
 NA
 No detectable BRCA1 deletion

aBRCA1 protein expression in class 1 represents markedly reduced or absent expression; expression levels in class 2 and class 3 represent reduced and wild-type expression, respectively. AI, allelic imbalance; ER, estrogen receptor; NA, not available; PR, progesterone receptor.

Birgisdottir et al. Breast Cancer Research 2006 8:R38   doi:10.1186/bcr1522