Table 2 |
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|
Adjusted ORs for breast cancer associated with hormone-related risk factors by ER/PR status |
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| Variables |
No. controls |
All cases versus controls |
ER+PR+ cases versus controls |
ER- PR- cases versus controls |
ER+PR+ cases versus ER- PR- cases |
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|
|
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| Number of cases |
OR (95% CI) |
Number of cases |
OR (95% CI) |
Number of cases |
OR (95% CI) |
OR (95% CI) |
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|
|
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| Age at menarche, years |
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| ≤ 11 |
90 |
400 |
1.00 |
188 |
1.00 |
92 |
1.00 |
1.00 |
| 12 |
109 |
532 |
1.13 (0.83–1.55) |
278 |
1.24 (0.88–1.75) |
119 |
1.18 (0.79–1.77) |
1.04 (0.74–1.47) |
| 13 |
121 |
475 |
0.88 (0.65–1.21) |
231 |
0.87 (0.62–1.24) |
110 |
0.94 (0.62–1.41) |
0.93 (0.65–1.33) |
| ≥ 14 |
120 |
318 |
0.61 (0.44–0.85) |
157 |
0.60 (0.42–0.86) |
64 |
0.59 (0.38–0.92) |
1.02 (0.67–1.53) |
| Trend p value |
0.0007 |
0.0006 |
0.008 |
0.85 |
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| Number of full-term pregnanciesa |
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| None |
125 |
564 |
1.00 |
301 |
1.00 |
113 |
1.00 |
1.00 |
| 1 |
85 |
347 |
0.91 (0.66–1.25) |
157 |
0.77 (0.55–1.10) |
82 |
1.06 (0.70–1.62) |
0.70 (0.49–1.02) |
| 2 |
139 |
492 |
0.81 (0.61–1.07) |
251 |
0.77 (0.57–1.06) |
106 |
0.95 (0.64–1.39) |
0.84 (0.60–1.18) |
| 3 |
56 |
224 |
0.81 (0.56–1.18) |
100 |
0.69 (0.45–1.04) |
54 |
1.06 (0.65–1.73) |
0.68 (0.44–1.05) |
| ≥ 4 |
35 |
98 |
0.49 (0.31–0.78) |
45 |
0.47 (0.28–0.80) |
30 |
0.72 (0.39–1.33) |
0.65 (0.37–1.15) |
| Trend p value |
0.008 |
0.005 |
0.50 |
0.09 |
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| Age at first full-term pregnancy for parous women, yearsa,b |
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| <22 |
68 |
316 |
1.00 |
126 |
1.00 |
96 |
1.00 |
1.00 |
| 22–27 |
89 |
333 |
1.07 (0.72–1.58) |
149 |
1.14 (0.73–1.78) |
81 |
0.92 (0.56–1.50) |
1.25 (0.81–1.94) |
| 28–31 |
78 |
265 |
1.03 (0.66–1.60) |
134 |
1.17 (0.71–1.93) |
57 |
0.82 (0.46–1.45) |
1.42 (0.85–2.37) |
| ≥ 32 |
80 |
247 |
0.92 (0.57–1.48) |
144 |
1.23 (0.72–2.10) |
38 |
0.56 (0.30–1.07) |
2.22 (1.24–3.98) |
| Trend p value |
0.65 |
0.49 |
0.08 |
0.009 |
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| Duration of breastfeeding for parous women, monthsa,b |
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| 0 |
38 |
247 |
1.00 |
102 |
1.00 |
63 |
1.00 |
1.00 |
| <1 |
23 |
144 |
0.99 (0.56–1.77) |
65 |
1.01 (0.53–1.90) |
38 |
1.19 (0.59–2.39) |
0.82 (0.47–1.44) |
| 1–6 |
80 |
273 |
0.58 (0.37–0.91) |
131 |
0.57 (0.34–0.94) |
68 |
0.72 (0.41–1.27) |
0.77 (0.47–1.26) |
| 7–23 |
110 |
322 |
0.52 (0.33–0.82) |
165 |
0.52 (0.31–0.87) |
63 |
0.55 (0.31–0.98) |
0.97 (0.59–1.61) |
| ≥ 24 |
64 |
175 |
0.51 (0.30–0.86) |
90 |
0.49 (0.27–0.87) |
40 |
0.62 (0.32–1.21) |
0.77 (0.42–1.39) |
| Trend p value |
0.001 |
0.002 |
0.03 |
0.63 |
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| BMI 1 year before reference date, kg/m2 |
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| <25 |
257 |
939 |
1.00 |
495 |
1.00 |
183 |
1.00 |
1.00 |
| 25–29 |
95 |
425 |
1.18 (0.89–1.55) |
209 |
1.11 (0.82–1.50) |
101 |
1.41 (0.99–2.02) |
0.81 (0.59–1.10) |
| 30–34 |
51 |
221 |
1.01 (0.70–1.44) |
94 |
0.88 (0.59–1.30) |
61 |
1.43 (0.91–2.23) |
0.60 (0.40–0.89) |
| ≥ 35 |
37 |
140 |
0.88 (0.58–1.34) |
56 |
0.69 (0.43–1.11) |
40 |
1.18 (0.70–2.01) |
0.61 (0.38–0.99) |
| Trend p value |
0.82 |
0.20 |
0.16 |
0.005 |
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| Duration of COC use, years |
||||||||
| Never |
47 |
244 |
1.00 |
128 |
1.00 |
47 |
1.00 |
1.00 |
| <1 |
73 |
295 |
0.78 (0.51–1.18) |
133 |
0.70 (0.44–1.12) |
59 |
0.76 (0.43–1.33) |
0.93 (0.57–1.52) |
| 1–4 |
108 |
429 |
0.80 (0.54–1.19) |
227 |
0.81 (0.53–1.25) |
90 |
0.87 (0.52–1.46) |
0.92 (0.59–1.43) |
| 5–9 |
115 |
362 |
0.62 (0.42–0.93) |
173 |
0.57 (0.37–0.88) |
90 |
0.82 (0.49–1.37) |
0.71 (0.45–1.12) |
| ≥ 10 |
97 |
395 |
0.84 (0.56–1.26) |
193 |
0.76 (0.49–1.18) |
99 |
1.27 (0.75–2.14) |
0.61 (0.39–0.96) |
| Trend p value |
0.30 |
0.16 |
0.18 |
0.008 |
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| Alcohol drinking status during reference agec |
||||||||
| Never |
141 |
558 |
1.00 |
251 |
1.00 |
138 |
1.00 |
1.00 |
| Former |
90 |
328 |
0.96 (0.71–1.31) |
162 |
1.02 (0.72–1.44) |
74 |
0.88 (0.59–1.33) |
1.14 (0.79–1.64) |
| Current |
209 |
839 |
1.05 (0.81–1.36) |
441 |
1.17 (0.88–1.55) |
173 |
0.93 (0.67–1.30) |
1.25 (0.93–1.68) |
| Average number of alcoholic drinks per week in recent 5 years |
||||||||
| Never |
141 |
558 |
1.00 |
251 |
1.00 |
138 |
1.00 |
1.00 |
| <3 |
130 |
481 |
1.01 (0.76–1.35) |
248 |
1.11 (0.81–1.53) |
101 |
0.89 (0.61–1.30) |
1.22 (0.87–1.71) |
| 3–5 |
49 |
171 |
0.93 (0.63–1.37) |
90 |
1.01 (0.66–1.54) |
34 |
0.76 (0.45–1.28) |
1.31 (0.81–2.11) |
| 6–11 |
32 |
157 |
1.16 (0.75–1.81) |
82 |
1.26 (0.78–2.03) |
34 |
1.06 (0.60–1.86) |
1.20 (0.74–1.94) |
| > 12 |
17 |
127 |
1.77 (1.01–3.08) |
68 |
2.10 (1.17–3.79) |
27 |
1.71 (0.87–3.38) |
1.24 (0.73–2.09) |
| Trend p value |
0.12 |
0.03 |
0.42 |
0.23 |
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| Drinking alcohol but not in the recent five years |
71 |
231 |
0.88 (0.63–1.22) |
115 |
0.92 (0.63–1.34) |
51 |
0.80 (0.51–1.26) |
1.14 (0.76–1.73) |
|
|
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|
ORs are from multivariable unconditional logistic regression models with the adjustment for race, age, education, first-degree breast cancer family history, age at menarche, gravidity, number of full-term pregnancies, BMI 1 year before reference date, COC use, the average number of alcoholic drinks per week in the recent 5 years, a variable combining menopausal status and hormone therapy use except where otherwise noted. BMI, body mass index; COC, combined oral contraceptive; CI, confidence interval; ER, estrogen receptor; OR, odds ratio; PR, progesterone receptor. aModels did not include gravidity. bAge at first full-term pregnancy and duration of breastfeeding mutually adjusted for each other. cAlcohol drinking status during reference age replaced the number of alcoholic drinks per week in the recent 5 years in the models. |
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|
Ma et al. Breast Cancer Research 2006 8:R39 doi:10.1186/bcr1514 |
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